Stimulation of soluble guanylate cyclase by vericiguat reduces skeletal muscle atrophy of mice following chemotherapy

Stimulation of soluble guanylate cyclase by vericiguat reduces skeletal muscle atrophy of mice following chemotherapy

Background: The chemotherapeutic doxorubicin (DOX) promotes severe skeletal muscle atrophy, which induces skeletal muscle weakness and fatigue. Soluble guanylate cyclase (sGC) contributes to a variety of pathophysiological processes, but whether it is involved in DOX-induced skeletal muscle atrophy...

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Bibliographic Details
Main Authors: Bo-ang Hu, Yu-lin Li, Hai-tao Han, Bin Lu, Xu Jia, Lu Han, Wei-xuan Ma, Ping Zhu, Zhi-hao Wang, Wei Zhang, Ming Zhong, Lei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
doxorubicin
soluble guanylate cyclase
skeletal muscle atrophy
protein synthesis
protein degradation
vericiguat
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1112123/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1112123/full

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