Inhibition of Yes-Associated Protein by Verteporfin Ameliorates Unilateral Ureteral Obstruction-Induced Renal Tubulointerstitial Inflammation and Fibrosis

Inhibition of Yes-Associated Protein by Verteporfin Ameliorates Unilateral Ureteral Obstruction-Induced Renal Tubulointerstitial Inflammation and Fibrosis

Yes-associated protein (YAP) activation after acute ischemic kidney injury might be related to interstitial fibrosis and impaired renal tubular regeneration. Verteporfin (VP) is a photosensitizer used in photodynamic therapy to treat age-related macular degeneration. In cancer cells, VP inhibits TEA...

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Bibliographic Details
Main Authors: Jixiu Jin, Tian Wang, Woong Park, Wenjia Li, Won Kim, Sung Kwang Park, Kyung Pyo Kang
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
kidney fibrosis
inflammation
myofibroblast activation
extracellular matrix
Hippo pathway
verteporfin
Online Access:https://www.mdpi.com/1422-0067/21/21/8184

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