Type 1 Conventional CD103+ Dendritic Cells Control Effector CD8+ T Cell Migration, Survival, and Memory Responses During Influenza Infection

Type 1 Conventional CD103+ Dendritic Cells Control Effector CD8+ T Cell Migration, Survival, and Memory Responses During Influenza Infection

Type 1 conventional CD103+ dendritic cells (cDC1) contribute significantly to the cytotoxic T lymphocyte (CTL) response during influenza virus infection; however, the mechanisms by which cDC1s promote CTL recruitment and viral clearance are unclear. We demonstrate that cDC1 ablation leads to a defic...

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Bibliographic Details
Main Authors: See Liang Ng, Yi Juan Teo, Yolanda Aphrilia Setiagani, Klaus Karjalainen, Christiane Ruedl
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
influenza
dendritic cell
CD103
CD8+ T cell
migration
survival
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03043/full

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