Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet
<p>Abstract</p> <p>Background</p> <p><it>Nelumbo nucifera</it>, known as sacred lotus, is a well-known medicinal plant and this lotus root is commonly used as food compared to different parts of this plant. This study was conducted to investigate the antioxi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-08-01
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| Series: | Journal of Biomedical Science |
| _version_ | 1811245206516793344 |
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| author | Du Huan Zhao Xu You Jeong-Soon Park Ji-Yeon Kim Sung-Hoon Chang Kyung-Ja |
| author_facet | Du Huan Zhao Xu You Jeong-Soon Park Ji-Yeon Kim Sung-Hoon Chang Kyung-Ja |
| author_sort | Du Huan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p><it>Nelumbo nucifera</it>, known as sacred lotus, is a well-known medicinal plant and this lotus root is commonly used as food compared to different parts of this plant. This study was conducted to investigate the antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in high fat diet-induced obese rats.</p> <p>Methods</p> <p>Thirty-two male Sprague-Dawley rats (4-week-old) were randomly divided into four groups (n=8) for 6 weeks (normal diet, N group; high fat diet, HF group; high fat diet + lotus root hot water extract, HFR group; high fat diet + lotus root hot water extract + taurine, HFRT group). Lotus root hot water extract was orally administrated (400mg/kg/day) to HFR and HFRT groups and the same amount of distilled water was orally administered to N and HF groups. Taurine was supplemented by dissolving in feed water (3% w/v).</p> <p>Results</p> <p>The activities of glutamate oxaloacetate transaminase and glutamate pyruvate transaminase in serum were lower in HFR and HFRT groups compared to HF group. Thiobarbituric acid reactive substance contents in all groups fed a high fat diet were higher compared to N group. The activities of hepatic antioxidant enzymes were higher in HFR and HFRT groups compared to HF group.</p> <p>Conclusions</p> <p>These results suggest that lotus root hot water extract with taurine supplementation shows antioxidant and hepatic protective effects in high fat diet-induced obese rats.</p> |
| first_indexed | 2024-04-12T14:36:30Z |
| format | Article |
| id | doaj.art-ca6fe7eeb4214a719e00d97063fb6d57 |
| institution | Directory Open Access Journal |
| issn | 1021-7770 1423-0127 |
| language | English |
| last_indexed | 2024-04-12T14:36:30Z |
| publishDate | 2010-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-ca6fe7eeb4214a719e00d97063fb6d572022-12-22T03:29:04ZengBMCJournal of Biomedical Science1021-77701423-01272010-08-0117Suppl 1S3910.1186/1423-0127-17-S1-S39Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat dietDu HuanZhao XuYou Jeong-SoonPark Ji-YeonKim Sung-HoonChang Kyung-Ja<p>Abstract</p> <p>Background</p> <p><it>Nelumbo nucifera</it>, known as sacred lotus, is a well-known medicinal plant and this lotus root is commonly used as food compared to different parts of this plant. This study was conducted to investigate the antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in high fat diet-induced obese rats.</p> <p>Methods</p> <p>Thirty-two male Sprague-Dawley rats (4-week-old) were randomly divided into four groups (n=8) for 6 weeks (normal diet, N group; high fat diet, HF group; high fat diet + lotus root hot water extract, HFR group; high fat diet + lotus root hot water extract + taurine, HFRT group). Lotus root hot water extract was orally administrated (400mg/kg/day) to HFR and HFRT groups and the same amount of distilled water was orally administered to N and HF groups. Taurine was supplemented by dissolving in feed water (3% w/v).</p> <p>Results</p> <p>The activities of glutamate oxaloacetate transaminase and glutamate pyruvate transaminase in serum were lower in HFR and HFRT groups compared to HF group. Thiobarbituric acid reactive substance contents in all groups fed a high fat diet were higher compared to N group. The activities of hepatic antioxidant enzymes were higher in HFR and HFRT groups compared to HF group.</p> <p>Conclusions</p> <p>These results suggest that lotus root hot water extract with taurine supplementation shows antioxidant and hepatic protective effects in high fat diet-induced obese rats.</p> |
| spellingShingle | Du Huan Zhao Xu You Jeong-Soon Park Ji-Yeon Kim Sung-Hoon Chang Kyung-Ja Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet Journal of Biomedical Science |
| title | Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet |
| title_full | Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet |
| title_fullStr | Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet |
| title_full_unstemmed | Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet |
| title_short | Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet |
| title_sort | antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet |
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