The Effect of Incompletely Administered Antenatal Corticosteroids on Neonatal Pulmonary Outcomes in Late Preterm Infants
Purpose Recent obstetric guidelines recommend the administration of antenatal corticosteroids in pregnant women at risk of delivering infants at a gestational age between 34 and 36 weeks. We examined the effect of incompletely administered antenatal corticosteroids on the neonatal pulmonary outcomes...
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| Format: | Article |
| Language: | English |
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Korean Society of Neonatology
2022-05-01
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| Series: | Neonatal Medicine |
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| Online Access: | http://neo-med.org/upload/pdf/nm-2022-29-2-84.pdf |
| _version_ | 1811276724059504640 |
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| author | Hyunsu Kim Mijin Kim Young Hwa Jung Chang Won Choi |
| author_facet | Hyunsu Kim Mijin Kim Young Hwa Jung Chang Won Choi |
| author_sort | Hyunsu Kim |
| collection | DOAJ |
| description | Purpose Recent obstetric guidelines recommend the administration of antenatal corticosteroids in pregnant women at risk of delivering infants at a gestational age between 34 and 36 weeks. We examined the effect of incompletely administered antenatal corticosteroids on the neonatal pulmonary outcomes in late preterm infants. Methods Late preterm infants (34+0 to 36+6 weeks gestational age) born at the Seoul National University Bundang Hospital from January 2019 to June 2020 were retrospectively enrolled. We excluded multiple births except twins, those with major congenital anomalies, deaths, or transfers to other hospitals. An incomplete course of antenatal corticosteroids was defined as one in which the first or the second dose of betamethasone was administered within 24 hours before delivery. The rates of neonatal pulmonary morbidities were compared between late preterm infants given incomplete courses antenatal corticosteroids and their peers who not given antenatal corticosteroids; these morbidities included respiratory distress syndrome and transient tachypnea of the newborn, assisted ventilation including invasive mechanical ventilation, nasal continuous positive airway pressure and high-flow nasal cannula, and admission to neonatal intensive care unit. Results Logistic regression models were constructed while adjusting for factors which were significant in bivariate models. After adjusting for baseline maternal and neonatal characteristics, we found no significant differences in the rates of neonatal pulmonary morbidities, assisted ventilation, or admission to the neonatal intensive care unit between late preterm infants who received incomplete antenatal corticosteroid therapy and their peers who were not given any antenatal corticosteroids. Conclusion Incompletely administered antenatal corticosteroids did not significantly alter the neonatal pulmonary outcomes in late preterm infants. |
| first_indexed | 2024-04-13T00:02:48Z |
| format | Article |
| id | doaj.art-ca7231687e4b447386dc148db6a65176 |
| institution | Directory Open Access Journal |
| issn | 2287-9412 2287-9803 |
| language | English |
| last_indexed | 2024-04-13T00:02:48Z |
| publishDate | 2022-05-01 |
| publisher | Korean Society of Neonatology |
| record_format | Article |
| series | Neonatal Medicine |
| spelling | doaj.art-ca7231687e4b447386dc148db6a651762022-12-22T03:11:19ZengKorean Society of NeonatologyNeonatal Medicine2287-94122287-98032022-05-01292849010.5385/nm.2022.29.2.841061The Effect of Incompletely Administered Antenatal Corticosteroids on Neonatal Pulmonary Outcomes in Late Preterm InfantsHyunsu Kim0Mijin Kim1Young Hwa Jung2Chang Won Choi3 Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, Korea Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, KoreaPurpose Recent obstetric guidelines recommend the administration of antenatal corticosteroids in pregnant women at risk of delivering infants at a gestational age between 34 and 36 weeks. We examined the effect of incompletely administered antenatal corticosteroids on the neonatal pulmonary outcomes in late preterm infants. Methods Late preterm infants (34+0 to 36+6 weeks gestational age) born at the Seoul National University Bundang Hospital from January 2019 to June 2020 were retrospectively enrolled. We excluded multiple births except twins, those with major congenital anomalies, deaths, or transfers to other hospitals. An incomplete course of antenatal corticosteroids was defined as one in which the first or the second dose of betamethasone was administered within 24 hours before delivery. The rates of neonatal pulmonary morbidities were compared between late preterm infants given incomplete courses antenatal corticosteroids and their peers who not given antenatal corticosteroids; these morbidities included respiratory distress syndrome and transient tachypnea of the newborn, assisted ventilation including invasive mechanical ventilation, nasal continuous positive airway pressure and high-flow nasal cannula, and admission to neonatal intensive care unit. Results Logistic regression models were constructed while adjusting for factors which were significant in bivariate models. After adjusting for baseline maternal and neonatal characteristics, we found no significant differences in the rates of neonatal pulmonary morbidities, assisted ventilation, or admission to the neonatal intensive care unit between late preterm infants who received incomplete antenatal corticosteroid therapy and their peers who were not given any antenatal corticosteroids. Conclusion Incompletely administered antenatal corticosteroids did not significantly alter the neonatal pulmonary outcomes in late preterm infants.http://neo-med.org/upload/pdf/nm-2022-29-2-84.pdflate preterm infantantenatal corticosteroidrespiratory morbidity |
| spellingShingle | Hyunsu Kim Mijin Kim Young Hwa Jung Chang Won Choi The Effect of Incompletely Administered Antenatal Corticosteroids on Neonatal Pulmonary Outcomes in Late Preterm Infants Neonatal Medicine late preterm infant antenatal corticosteroid respiratory morbidity |
| title | The Effect of Incompletely Administered Antenatal Corticosteroids on Neonatal Pulmonary Outcomes in Late Preterm Infants |
| title_full | The Effect of Incompletely Administered Antenatal Corticosteroids on Neonatal Pulmonary Outcomes in Late Preterm Infants |
| title_fullStr | The Effect of Incompletely Administered Antenatal Corticosteroids on Neonatal Pulmonary Outcomes in Late Preterm Infants |
| title_full_unstemmed | The Effect of Incompletely Administered Antenatal Corticosteroids on Neonatal Pulmonary Outcomes in Late Preterm Infants |
| title_short | The Effect of Incompletely Administered Antenatal Corticosteroids on Neonatal Pulmonary Outcomes in Late Preterm Infants |
| title_sort | effect of incompletely administered antenatal corticosteroids on neonatal pulmonary outcomes in late preterm infants |
| topic | late preterm infant antenatal corticosteroid respiratory morbidity |
| url | http://neo-med.org/upload/pdf/nm-2022-29-2-84.pdf |
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