Polycomb repressive complex 2 controls cardiac cell fate decision via interacting with RNA: Promiscuously or well-ordered
The epigenetic landscape determines cell fate during heart development. Polycomb repressive complex 2 (PRC2) mediates histone methyltransferase activity during cardiac cell differentiation. The PRC2 complex contains the proteins embryonic ectoderm development (EED), suppressor of zeste (SUZ12), the...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.1011228/full |
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| author | Gang Wang Heng Ye Heng Ye Xuchao Wang Xuchao Wang Binbin Liu |
| author_facet | Gang Wang Heng Ye Heng Ye Xuchao Wang Xuchao Wang Binbin Liu |
| author_sort | Gang Wang |
| collection | DOAJ |
| description | The epigenetic landscape determines cell fate during heart development. Polycomb repressive complex 2 (PRC2) mediates histone methyltransferase activity during cardiac cell differentiation. The PRC2 complex contains the proteins embryonic ectoderm development (EED), suppressor of zeste (SUZ12), the chromatin assembly factor 1 (CAF1) histone-binding proteins RBBP4 and RBBP7, and the histone methyltransferase called enhancer of zeste (EZH2 or EZH1), which incorporates the Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain. Cardiac PRC2-deficient mice display lethal congenital heart malformations. The dynamic process of cardiac cell fate decisions is controlled by PRC2 and the PRC2-mediated epigenetic landscape. Although specific individual long noncoding RNAs (lncRNAs) including Braveheart were widely reported to regulate the recruitments of PRC2 to their specific targets, a promiscuous RNA binding profile by PRC2 was also identified to play an essential role in cardiac cell fate decision. In this review, we focus on RNA-mediated PRC2 recruitment machinery in the process of cardiac cell fate decisions. The roles of individual lncRNAs which recruit PRC2, as well as promiscuous RNA binding by PRC2 in heart development are summarized. Since the binding priority of RNAs with different primary and secondary structures differs in its affinity to PRC2, the competitive relationship between individual lncRNAs binding and promiscuous RNA binding by PRC2 may be important for understanding the machinery by which biding of individual lncRNA and promiscuous RNA by PRC2 coordinately control the well-ordered dynamic cardiac cell lineage differentiation process. |
| first_indexed | 2024-04-12T13:35:56Z |
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| id | doaj.art-ca7242d19d2f459aaa794ce12c4b49bf |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-12T13:35:56Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Genetics |
| spelling | doaj.art-ca7242d19d2f459aaa794ce12c4b49bf2022-12-22T03:31:01ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-10-011310.3389/fgene.2022.10112281011228Polycomb repressive complex 2 controls cardiac cell fate decision via interacting with RNA: Promiscuously or well-orderedGang Wang0Heng Ye1Heng Ye2Xuchao Wang3Xuchao Wang4Binbin Liu5Xiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Xiamen, ChinaXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Xiamen, ChinaSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning, ChinaXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Xiamen, ChinaSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, ChinaXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Xiamen, ChinaThe epigenetic landscape determines cell fate during heart development. Polycomb repressive complex 2 (PRC2) mediates histone methyltransferase activity during cardiac cell differentiation. The PRC2 complex contains the proteins embryonic ectoderm development (EED), suppressor of zeste (SUZ12), the chromatin assembly factor 1 (CAF1) histone-binding proteins RBBP4 and RBBP7, and the histone methyltransferase called enhancer of zeste (EZH2 or EZH1), which incorporates the Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain. Cardiac PRC2-deficient mice display lethal congenital heart malformations. The dynamic process of cardiac cell fate decisions is controlled by PRC2 and the PRC2-mediated epigenetic landscape. Although specific individual long noncoding RNAs (lncRNAs) including Braveheart were widely reported to regulate the recruitments of PRC2 to their specific targets, a promiscuous RNA binding profile by PRC2 was also identified to play an essential role in cardiac cell fate decision. In this review, we focus on RNA-mediated PRC2 recruitment machinery in the process of cardiac cell fate decisions. The roles of individual lncRNAs which recruit PRC2, as well as promiscuous RNA binding by PRC2 in heart development are summarized. Since the binding priority of RNAs with different primary and secondary structures differs in its affinity to PRC2, the competitive relationship between individual lncRNAs binding and promiscuous RNA binding by PRC2 may be important for understanding the machinery by which biding of individual lncRNA and promiscuous RNA by PRC2 coordinately control the well-ordered dynamic cardiac cell lineage differentiation process.https://www.frontiersin.org/articles/10.3389/fgene.2022.1011228/fullheart developmentPRC2promiscuous RNA bindinglncRNAcardiac cell fate decisions |
| spellingShingle | Gang Wang Heng Ye Heng Ye Xuchao Wang Xuchao Wang Binbin Liu Polycomb repressive complex 2 controls cardiac cell fate decision via interacting with RNA: Promiscuously or well-ordered Frontiers in Genetics heart development PRC2 promiscuous RNA binding lncRNA cardiac cell fate decisions |
| title | Polycomb repressive complex 2 controls cardiac cell fate decision via interacting with RNA: Promiscuously or well-ordered |
| title_full | Polycomb repressive complex 2 controls cardiac cell fate decision via interacting with RNA: Promiscuously or well-ordered |
| title_fullStr | Polycomb repressive complex 2 controls cardiac cell fate decision via interacting with RNA: Promiscuously or well-ordered |
| title_full_unstemmed | Polycomb repressive complex 2 controls cardiac cell fate decision via interacting with RNA: Promiscuously or well-ordered |
| title_short | Polycomb repressive complex 2 controls cardiac cell fate decision via interacting with RNA: Promiscuously or well-ordered |
| title_sort | polycomb repressive complex 2 controls cardiac cell fate decision via interacting with rna promiscuously or well ordered |
| topic | heart development PRC2 promiscuous RNA binding lncRNA cardiac cell fate decisions |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.1011228/full |
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