Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
Diffuse Intrinsic Pontine Gliomas are diagnosed by sampling a small portion of the tumour. Here, using multiple samples from tumours, the authors analyse the spatial and temporal distribution of driver mutations revealing that H3K27M mutations arise first in tumorigenesis followed by a specific inva...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11185 |
| _version_ | 1818841588746420224 |
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| author | Hamid Nikbakht Eshini Panditharatna Leonie G. Mikael Rui Li Tenzin Gayden Matthew Osmond Cheng-Ying Ho Madhuri Kambhampati Eugene I. Hwang Damien Faury Alan Siu Simon Papillon-Cavanagh Denise Bechet Keith L. Ligon Benjamin Ellezam Wendy J. Ingram Caedyn Stinson Andrew S. Moore Katherine E. Warren Jason Karamchandani Roger J. Packer Nada Jabado Jacek Majewski Javad Nazarian |
| author_facet | Hamid Nikbakht Eshini Panditharatna Leonie G. Mikael Rui Li Tenzin Gayden Matthew Osmond Cheng-Ying Ho Madhuri Kambhampati Eugene I. Hwang Damien Faury Alan Siu Simon Papillon-Cavanagh Denise Bechet Keith L. Ligon Benjamin Ellezam Wendy J. Ingram Caedyn Stinson Andrew S. Moore Katherine E. Warren Jason Karamchandani Roger J. Packer Nada Jabado Jacek Majewski Javad Nazarian |
| author_sort | Hamid Nikbakht |
| collection | DOAJ |
| description | Diffuse Intrinsic Pontine Gliomas are diagnosed by sampling a small portion of the tumour. Here, using multiple samples from tumours, the authors analyse the spatial and temporal distribution of driver mutations revealing that H3K27M mutations arise first in tumorigenesis followed by a specific invariable sequence of driver mutations, which are homogeneously distributed across the tumour mass. |
| first_indexed | 2024-12-19T04:28:28Z |
| format | Article |
| id | doaj.art-ca732472c78c4cee9e8f045e01b29088 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:28:28Z |
| publishDate | 2016-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ca732472c78c4cee9e8f045e01b290882022-12-21T20:35:58ZengNature PortfolioNature Communications2041-17232016-04-01711810.1038/ncomms11185Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine gliomaHamid Nikbakht0Eshini Panditharatna1Leonie G. Mikael2Rui Li3Tenzin Gayden4Matthew Osmond5Cheng-Ying Ho6Madhuri Kambhampati7Eugene I. Hwang8Damien Faury9Alan Siu10Simon Papillon-Cavanagh11Denise Bechet12Keith L. Ligon13Benjamin Ellezam14Wendy J. Ingram15Caedyn Stinson16Andrew S. Moore17Katherine E. Warren18Jason Karamchandani19Roger J. Packer20Nada Jabado21Jacek Majewski22Javad Nazarian23Department of Human Genetics, McGill UniversityResearch Center for Genetic Medicine, Children’s National Health SystemDepartment of Pediatrics, McGill University and McGill University Heath Centre Research InstituteDepartment of Human Genetics, McGill UniversityDepartment of Human Genetics, McGill UniversityDepartment of Human Genetics, McGill UniversityDivision of Pathology, Children’s National Health SystemResearch Center for Genetic Medicine, Children’s National Health SystemCenter for Cancer and Blood Disorders, Children’s National Health SystemDepartment of Pediatrics, McGill University and McGill University Heath Centre Research InstituteThe Department of Neurological Surgery, George Washington University School of Medicine and Health SciencesDepartment of Human Genetics, McGill UniversityDepartment of Human Genetics, McGill UniversityDepartment of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer InstituteDepartment of Pathology, CHU Ste-Justine, Université de MontréalUQ Child Health Research Centre, The University of QueenslandUniversity of Queensland Diamantina Institute, The University of QueenslandUQ Child Health Research Centre, The University of QueenslandNational Cancer Institute, National Institute of HealthDepartment of Pathology, Montreal Neurological Hospital, McGill UniversityBrain Tumour Institute, Center for Neuroscience and Behavioral Medicine, Children’s National Health SystemDepartment of Human Genetics, McGill UniversityDepartment of Human Genetics, McGill UniversityResearch Center for Genetic Medicine, Children’s National Health SystemDiffuse Intrinsic Pontine Gliomas are diagnosed by sampling a small portion of the tumour. Here, using multiple samples from tumours, the authors analyse the spatial and temporal distribution of driver mutations revealing that H3K27M mutations arise first in tumorigenesis followed by a specific invariable sequence of driver mutations, which are homogeneously distributed across the tumour mass.https://doi.org/10.1038/ncomms11185 |
| spellingShingle | Hamid Nikbakht Eshini Panditharatna Leonie G. Mikael Rui Li Tenzin Gayden Matthew Osmond Cheng-Ying Ho Madhuri Kambhampati Eugene I. Hwang Damien Faury Alan Siu Simon Papillon-Cavanagh Denise Bechet Keith L. Ligon Benjamin Ellezam Wendy J. Ingram Caedyn Stinson Andrew S. Moore Katherine E. Warren Jason Karamchandani Roger J. Packer Nada Jabado Jacek Majewski Javad Nazarian Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma Nature Communications |
| title | Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma |
| title_full | Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma |
| title_fullStr | Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma |
| title_full_unstemmed | Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma |
| title_short | Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma |
| title_sort | spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma |
| url | https://doi.org/10.1038/ncomms11185 |
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