The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus
Inflammation and atherogenic dyslipidaemia are often observed in skin diseases and represent an increased risk of cardiovascular disorders. Proprotein convertase subtilisin/kexin type 9 plays an important role in the regulation of serum low-density lipoprotein cholesterol levels. Its biological role...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2022-09-01
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| Series: | Advances in Dermatology and Allergology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/The-role-of-proprotein-convertase-subtilisin-kexin-type-9-r-n-PCSK9-in-the-pathophysiology-of-psoriasis-and-systemic-r-nlupus-erythematosus,7,47672,1,1.html |
| _version_ | 1797943469956661248 |
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| author | Aleksandra Frątczak Karina Polak Michał Szczepanek Anna Lis-Święty |
| author_facet | Aleksandra Frątczak Karina Polak Michał Szczepanek Anna Lis-Święty |
| author_sort | Aleksandra Frątczak |
| collection | DOAJ |
| description | Inflammation and atherogenic dyslipidaemia are often observed in skin diseases and represent an increased risk of cardiovascular disorders. Proprotein convertase subtilisin/kexin type 9 plays an important role in the regulation of serum low-density lipoprotein cholesterol levels. Its biological role, however, seems to go much beyond the regulation of cholesterol metabolism. The article presents potential pathophysiological links between inflammatory process and lipid disorders based on the example of psoriasis and systemic lupus erythematosus. |
| first_indexed | 2024-04-10T20:24:41Z |
| format | Article |
| id | doaj.art-ca737075d8d0447f942112799a0b7928 |
| institution | Directory Open Access Journal |
| issn | 1642-395X 2299-0046 |
| language | English |
| last_indexed | 2024-04-10T20:24:41Z |
| publishDate | 2022-09-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Advances in Dermatology and Allergology |
| spelling | doaj.art-ca737075d8d0447f942112799a0b79282023-01-25T13:30:15ZengTermedia Publishing HouseAdvances in Dermatology and Allergology1642-395X2299-00462022-09-0139464565010.5114/ada.2022.11891947672The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosusAleksandra FrątczakKarina PolakMichał SzczepanekAnna Lis-ŚwiętyInflammation and atherogenic dyslipidaemia are often observed in skin diseases and represent an increased risk of cardiovascular disorders. Proprotein convertase subtilisin/kexin type 9 plays an important role in the regulation of serum low-density lipoprotein cholesterol levels. Its biological role, however, seems to go much beyond the regulation of cholesterol metabolism. The article presents potential pathophysiological links between inflammatory process and lipid disorders based on the example of psoriasis and systemic lupus erythematosus.https://www.termedia.pl/The-role-of-proprotein-convertase-subtilisin-kexin-type-9-r-n-PCSK9-in-the-pathophysiology-of-psoriasis-and-systemic-r-nlupus-erythematosus,7,47672,1,1.htmlpcsk9 evolocumab alirocumab psoriasis systemic lupus erythematosus |
| spellingShingle | Aleksandra Frątczak Karina Polak Michał Szczepanek Anna Lis-Święty The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the pathophysiology of psoriasis and systemic lupus erythematosus Advances in Dermatology and Allergology pcsk9 evolocumab alirocumab psoriasis systemic lupus erythematosus |
| title | The role of proprotein convertase subtilisin/kexin type 9
(PCSK9) in the pathophysiology of psoriasis and systemic
lupus erythematosus |
| title_full | The role of proprotein convertase subtilisin/kexin type 9
(PCSK9) in the pathophysiology of psoriasis and systemic
lupus erythematosus |
| title_fullStr | The role of proprotein convertase subtilisin/kexin type 9
(PCSK9) in the pathophysiology of psoriasis and systemic
lupus erythematosus |
| title_full_unstemmed | The role of proprotein convertase subtilisin/kexin type 9
(PCSK9) in the pathophysiology of psoriasis and systemic
lupus erythematosus |
| title_short | The role of proprotein convertase subtilisin/kexin type 9
(PCSK9) in the pathophysiology of psoriasis and systemic
lupus erythematosus |
| title_sort | role of proprotein convertase subtilisin kexin type 9 pcsk9 in the pathophysiology of psoriasis and systemic lupus erythematosus |
| topic | pcsk9 evolocumab alirocumab psoriasis systemic lupus erythematosus |
| url | https://www.termedia.pl/The-role-of-proprotein-convertase-subtilisin-kexin-type-9-r-n-PCSK9-in-the-pathophysiology-of-psoriasis-and-systemic-r-nlupus-erythematosus,7,47672,1,1.html |
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