Quercetin inhibits cytotoxicity of PC12 cells induced by amyloid-beta 25–35 via stimulating estrogen receptor α, activating ERK1/2, and inhibiting apoptosis

Quercetin inhibits cytotoxicity of PC12 cells induced by amyloid-beta 25–35 via stimulating estrogen receptor α, activating ERK1/2, and inhibiting apoptosis

The accumulation of β-amyloid (Aβ) in the brain plays an important role in the pathogenesis of Alzheimer’s disease (AD). The lack of estrogen is one of the risk factors for AD. Quercetin is a phytoestrogen with a chemical structure similar to that of estrogen. However, the mechanism by which quercet...

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Bibliographic Details
Main Authors: Liu Liangjing, Liu Yang, Zhen Yanjie, Guo Tonglin, Wang Cui, Shen Lixia, Li Wei
Format: Article
Language:English
Published: De Gruyter 2022-03-01
Series:Open Life Sciences
Subjects:
quercetin
alzheimer’s disease
mapk pathway
estrogen receptor
protective estrogen-like properties
Online Access:https://doi.org/10.1515/biol-2021-0014

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