Helicobacter pylori infection—A risk factor for lipid peroxidation and superoxide dismutase over‐activity: A cross‐sectional study among patients with dyspepsia in Cameroon
Abstract Background and Aim There is an intimate relationship between oxidative stress and inflammation. Helicobacter pylori (H. pylori) infection leads to gastritis in almost all the hosts. So, we hypothesize that gastritis in H. pylori infection may be described as the accumulation of continuous o...
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.12958 |
| _version_ | 1797676510813880320 |
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| author | Ghislaine Florice Faujo Nintewoue Lionel Danny Tali Nguefak Ghislaine Ngatcha Sartre Michele Tagni Paul Talla Carole Marlyse Menzy Moungo‐Ndjole Laure Brigitte Kouitcheu Mabeku |
| author_facet | Ghislaine Florice Faujo Nintewoue Lionel Danny Tali Nguefak Ghislaine Ngatcha Sartre Michele Tagni Paul Talla Carole Marlyse Menzy Moungo‐Ndjole Laure Brigitte Kouitcheu Mabeku |
| author_sort | Ghislaine Florice Faujo Nintewoue |
| collection | DOAJ |
| description | Abstract Background and Aim There is an intimate relationship between oxidative stress and inflammation. Helicobacter pylori (H. pylori) infection leads to gastritis in almost all the hosts. So, we hypothesize that gastritis in H. pylori infection may be described as the accumulation of continuous oxidative damage. Methods The study was conducted from October 2020 to October 2021 at three reference health facilities in Cameroon. A total of 266 participants (131 males and 135 females) ranging from 15 to 88 years old with 48.28 ± 17.29 years as mean age were enrolled. Each participant gave a written informed consent and ethical committees approved the protocol. Biopsies samples were collected for H. pylori detection using histological examination and rapid urease test. Malondialdehyde (MDA) and glutathione (GSH) content, and catalase (CAT) and superoxide dismutase (SOD) activities were evaluated in serum as biomarkers of oxidative stress. Results Helicobacter pylori was detected in 71.80% of our sample population. Low income level was associated with higher GSH level (P = 0.0249) and having family history of gastric cancer to higher SOD activity (P = 0.0156). A significant higher MDA content (P < 0.0001) and SOD activity (P = 0.0235) was recorded among infected individuals compared with noninfected ones. A significantly higher MDA content and SOD activity was recorded among smokers (P = 0.0461) and participants older than 50 years old (P = 0.0491) with H. pylori positivity. Conclusion Our findings showed that H. pylori infection is associated with overproduction of reactive oxygen species and oxidative stress. The presence of this pathogen in elderly individuals or in smokers increased their risk for oxidative stress. |
| first_indexed | 2024-03-11T22:30:16Z |
| format | Article |
| id | doaj.art-ca7c86ef856a41af9a5b0a89e7f38c17 |
| institution | Directory Open Access Journal |
| issn | 2397-9070 |
| language | English |
| last_indexed | 2024-03-11T22:30:16Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj.art-ca7c86ef856a41af9a5b0a89e7f38c172023-09-23T10:54:38ZengWileyJGH Open2397-90702023-09-017961862810.1002/jgh3.12958Helicobacter pylori infection—A risk factor for lipid peroxidation and superoxide dismutase over‐activity: A cross‐sectional study among patients with dyspepsia in CameroonGhislaine Florice Faujo Nintewoue0Lionel Danny Tali Nguefak1Ghislaine Ngatcha2Sartre Michele Tagni3Paul Talla4Carole Marlyse Menzy Moungo‐Ndjole5Laure Brigitte Kouitcheu Mabeku6Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science University of Dschang Dschang CameroonMicrobiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science University of Dschang Dschang CameroonRegional Hospital Bafoussam Bafoussam CameroonCentre Médicale la Cathédrale Yaoundé CameroonGeneral Hospital Yaoundé Yaoundé CameroonGeneral Hospital Yaoundé Yaoundé CameroonMicrobiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science University of Dschang Dschang CameroonAbstract Background and Aim There is an intimate relationship between oxidative stress and inflammation. Helicobacter pylori (H. pylori) infection leads to gastritis in almost all the hosts. So, we hypothesize that gastritis in H. pylori infection may be described as the accumulation of continuous oxidative damage. Methods The study was conducted from October 2020 to October 2021 at three reference health facilities in Cameroon. A total of 266 participants (131 males and 135 females) ranging from 15 to 88 years old with 48.28 ± 17.29 years as mean age were enrolled. Each participant gave a written informed consent and ethical committees approved the protocol. Biopsies samples were collected for H. pylori detection using histological examination and rapid urease test. Malondialdehyde (MDA) and glutathione (GSH) content, and catalase (CAT) and superoxide dismutase (SOD) activities were evaluated in serum as biomarkers of oxidative stress. Results Helicobacter pylori was detected in 71.80% of our sample population. Low income level was associated with higher GSH level (P = 0.0249) and having family history of gastric cancer to higher SOD activity (P = 0.0156). A significant higher MDA content (P < 0.0001) and SOD activity (P = 0.0235) was recorded among infected individuals compared with noninfected ones. A significantly higher MDA content and SOD activity was recorded among smokers (P = 0.0461) and participants older than 50 years old (P = 0.0491) with H. pylori positivity. Conclusion Our findings showed that H. pylori infection is associated with overproduction of reactive oxygen species and oxidative stress. The presence of this pathogen in elderly individuals or in smokers increased their risk for oxidative stress.https://doi.org/10.1002/jgh3.12958antioxidant protective factorsHelicobacter pylori infectionlipid peroxidationoxidative stress |
| spellingShingle | Ghislaine Florice Faujo Nintewoue Lionel Danny Tali Nguefak Ghislaine Ngatcha Sartre Michele Tagni Paul Talla Carole Marlyse Menzy Moungo‐Ndjole Laure Brigitte Kouitcheu Mabeku Helicobacter pylori infection—A risk factor for lipid peroxidation and superoxide dismutase over‐activity: A cross‐sectional study among patients with dyspepsia in Cameroon JGH Open antioxidant protective factors Helicobacter pylori infection lipid peroxidation oxidative stress |
| title | Helicobacter pylori infection—A risk factor for lipid peroxidation and superoxide dismutase over‐activity: A cross‐sectional study among patients with dyspepsia in Cameroon |
| title_full | Helicobacter pylori infection—A risk factor for lipid peroxidation and superoxide dismutase over‐activity: A cross‐sectional study among patients with dyspepsia in Cameroon |
| title_fullStr | Helicobacter pylori infection—A risk factor for lipid peroxidation and superoxide dismutase over‐activity: A cross‐sectional study among patients with dyspepsia in Cameroon |
| title_full_unstemmed | Helicobacter pylori infection—A risk factor for lipid peroxidation and superoxide dismutase over‐activity: A cross‐sectional study among patients with dyspepsia in Cameroon |
| title_short | Helicobacter pylori infection—A risk factor for lipid peroxidation and superoxide dismutase over‐activity: A cross‐sectional study among patients with dyspepsia in Cameroon |
| title_sort | helicobacter pylori infection a risk factor for lipid peroxidation and superoxide dismutase over activity a cross sectional study among patients with dyspepsia in cameroon |
| topic | antioxidant protective factors Helicobacter pylori infection lipid peroxidation oxidative stress |
| url | https://doi.org/10.1002/jgh3.12958 |
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