Real-Life Experience with Sonidegib for Locally Advanced Basosquamous Carcinoma: A Case Series
Introduction: Basosquamous carcinoma is an uncommon subtype of basal cell carcinoma (BCC), characterized by aggressive local growth and metastatic potential, that mainly develops on the nose, perinasal area, and ears, representing 1.2–2.7% of all head-neck keratinocyte carcinomas. Although systemic...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2024-01-01
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| Series: | Case Reports in Dermatology |
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| Online Access: | https://beta.karger.com/Article/FullText/535506 |
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| author | Enrico Bocchino Simone Cappilli Gerardo Palmisano Andrea Paradisi Alfredo Piccerillo Alessandro Di Stefani Ketty Peris |
| author_facet | Enrico Bocchino Simone Cappilli Gerardo Palmisano Andrea Paradisi Alfredo Piccerillo Alessandro Di Stefani Ketty Peris |
| author_sort | Enrico Bocchino |
| collection | DOAJ |
| description | Introduction: Basosquamous carcinoma is an uncommon subtype of basal cell carcinoma (BCC), characterized by aggressive local growth and metastatic potential, that mainly develops on the nose, perinasal area, and ears, representing 1.2–2.7% of all head-neck keratinocyte carcinomas. Although systemic therapy with hedgehog inhibitors (HHIs) represents the first-line medical treatment in advanced BCC, to date, no standard therapy for advanced basosquamous carcinoma has been established. Herein, we reported a case series of patients affected by locally advanced basosquamous carcinomas, who were treated with HHIs. Case Presentation: Data of 5 patients receiving HHIs for locally advanced basosquamous carcinomas were retrieved (2 women and 3 males, age range: 63–89 years, average age of 77 years). Skin lesions were located on the head-neck area; in particular, 4 tumors involved orbital and periorbital area and 1 tumor developed in the retro-auricular region. A clinical response was obtained in 3 out of 5 patients (2 partial responses and 1 complete response), while disease progression was observed in the remaining 2 patients. Hence, therapy was interrupted, switching to surgery or immunotherapy. Conclusion: Increasing evidence suggests considering HHIs for large skin tumors developing in functionally and cosmetically sensitive areas, in patients with multiple comorbidities, although their use for basosquamous carcinoma require more exploration, large cohort populations, and long follow-up assessment. |
| first_indexed | 2024-03-08T08:52:37Z |
| format | Article |
| id | doaj.art-ca7eee912f234ca09b0cd7f7811445b1 |
| institution | Directory Open Access Journal |
| issn | 1662-6567 |
| language | English |
| last_indexed | 2024-03-08T08:52:37Z |
| publishDate | 2024-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Dermatology |
| spelling | doaj.art-ca7eee912f234ca09b0cd7f7811445b12024-02-01T08:03:26ZengKarger PublishersCase Reports in Dermatology1662-65672024-01-011611710.1159/000535506535506Real-Life Experience with Sonidegib for Locally Advanced Basosquamous Carcinoma: A Case SeriesEnrico Bocchino0Simone Cappilli1Gerardo Palmisano2Andrea Paradisi3Alfredo Piccerillo4Alessandro Di Stefani5Ketty Peris6Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyDermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyDermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyDermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyDermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyDermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyDermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyIntroduction: Basosquamous carcinoma is an uncommon subtype of basal cell carcinoma (BCC), characterized by aggressive local growth and metastatic potential, that mainly develops on the nose, perinasal area, and ears, representing 1.2–2.7% of all head-neck keratinocyte carcinomas. Although systemic therapy with hedgehog inhibitors (HHIs) represents the first-line medical treatment in advanced BCC, to date, no standard therapy for advanced basosquamous carcinoma has been established. Herein, we reported a case series of patients affected by locally advanced basosquamous carcinomas, who were treated with HHIs. Case Presentation: Data of 5 patients receiving HHIs for locally advanced basosquamous carcinomas were retrieved (2 women and 3 males, age range: 63–89 years, average age of 77 years). Skin lesions were located on the head-neck area; in particular, 4 tumors involved orbital and periorbital area and 1 tumor developed in the retro-auricular region. A clinical response was obtained in 3 out of 5 patients (2 partial responses and 1 complete response), while disease progression was observed in the remaining 2 patients. Hence, therapy was interrupted, switching to surgery or immunotherapy. Conclusion: Increasing evidence suggests considering HHIs for large skin tumors developing in functionally and cosmetically sensitive areas, in patients with multiple comorbidities, although their use for basosquamous carcinoma require more exploration, large cohort populations, and long follow-up assessment.https://beta.karger.com/Article/FullText/535506basosquamous carcinomasonic hedgehog pathway inhibitorsvismodegibsonidegibclinical dermatology |
| spellingShingle | Enrico Bocchino Simone Cappilli Gerardo Palmisano Andrea Paradisi Alfredo Piccerillo Alessandro Di Stefani Ketty Peris Real-Life Experience with Sonidegib for Locally Advanced Basosquamous Carcinoma: A Case Series Case Reports in Dermatology basosquamous carcinoma sonic hedgehog pathway inhibitors vismodegib sonidegib clinical dermatology |
| title | Real-Life Experience with Sonidegib for Locally Advanced Basosquamous Carcinoma: A Case Series |
| title_full | Real-Life Experience with Sonidegib for Locally Advanced Basosquamous Carcinoma: A Case Series |
| title_fullStr | Real-Life Experience with Sonidegib for Locally Advanced Basosquamous Carcinoma: A Case Series |
| title_full_unstemmed | Real-Life Experience with Sonidegib for Locally Advanced Basosquamous Carcinoma: A Case Series |
| title_short | Real-Life Experience with Sonidegib for Locally Advanced Basosquamous Carcinoma: A Case Series |
| title_sort | real life experience with sonidegib for locally advanced basosquamous carcinoma a case series |
| topic | basosquamous carcinoma sonic hedgehog pathway inhibitors vismodegib sonidegib clinical dermatology |
| url | https://beta.karger.com/Article/FullText/535506 |
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