Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population
<b>AIM:</b> To investigate the association between apolipoprotein E (<i>APOE</i>) -219 T>G promoter polymorphism and primary open angle glaucoma (POAG).<b>METHODS:</b> Patients and healthy subjects were genotyped with polymerase chain reaction-restriction f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2014-06-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067653/ |
| Summary: | <b>AIM:</b> To investigate the association between apolipoprotein E (<i>APOE</i>) -219 T>G promoter polymorphism and primary open angle glaucoma (POAG).<b>METHODS:</b> Patients and healthy subjects were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotype/allele frequencies were compared between 122 healthy subjects and in 75 POAG patients using Chi-square test.<b>RESULTS:</b>Although the frequency of <i>APOE</i> -219 GG genotype was higher in POAG group (13.3%) than in control group (6.6%), this finding was not statistically significant (<i>P</i>=0.09). In glaucoma patients carrying GG genotype, mean linear C/D ratio was higher and progression was more compared to glaucoma patients with GT genotype.<b>CONCLUSION:</b> <i>APOE</i> -219 T>G polymorphism does not seem to be a risk factor for the presence of glaucoma, but might play a role in deterioration of the disease, which needs further evaluation. |
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| ISSN: | 2222-3959 2227-4898 |