Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population
<b>AIM:</b> To investigate the association between apolipoprotein E (<i>APOE</i>) -219 T>G promoter polymorphism and primary open angle glaucoma (POAG).<b>METHODS:</b> Patients and healthy subjects were genotyped with polymerase chain reaction-restriction f...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2014-06-01
|
| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067653/ |
| _version_ | 1819231741235167232 |
|---|---|
| author | Emel Saglar Banu Bozkurt Murat Irkec |
| author_facet | Emel Saglar Banu Bozkurt Murat Irkec |
| author_sort | Emel Saglar |
| collection | DOAJ |
| description | <b>AIM:</b> To investigate the association between apolipoprotein E (<i>APOE</i>) -219 T>G promoter polymorphism and primary open angle glaucoma (POAG).<b>METHODS:</b> Patients and healthy subjects were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotype/allele frequencies were compared between 122 healthy subjects and in 75 POAG patients using Chi-square test.<b>RESULTS:</b>Although the frequency of <i>APOE</i> -219 GG genotype was higher in POAG group (13.3%) than in control group (6.6%), this finding was not statistically significant (<i>P</i>=0.09). In glaucoma patients carrying GG genotype, mean linear C/D ratio was higher and progression was more compared to glaucoma patients with GT genotype.<b>CONCLUSION:</b> <i>APOE</i> -219 T>G polymorphism does not seem to be a risk factor for the presence of glaucoma, but might play a role in deterioration of the disease, which needs further evaluation. |
| first_indexed | 2024-12-23T11:49:47Z |
| format | Article |
| id | doaj.art-ca810d06853643f898f8f962771904d7 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-23T11:49:47Z |
| publishDate | 2014-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-ca810d06853643f898f8f962771904d72022-12-21T17:48:14ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982014-06-017342643010.3980/j.issn.2222-3959.2014.03.07Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish populationEmel Saglar0Banu Bozkurt1Murat Irkec2Department of Molecular Biology, Faculty of Science, Hacettepe University, Ankara 06800, Turkey<br>Department of Ophthalmology, Selcuk University Faculty of Medicine, Konya 42131, Turkey<br>Department of Ophthalmology, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey<b>AIM:</b> To investigate the association between apolipoprotein E (<i>APOE</i>) -219 T>G promoter polymorphism and primary open angle glaucoma (POAG).<b>METHODS:</b> Patients and healthy subjects were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotype/allele frequencies were compared between 122 healthy subjects and in 75 POAG patients using Chi-square test.<b>RESULTS:</b>Although the frequency of <i>APOE</i> -219 GG genotype was higher in POAG group (13.3%) than in control group (6.6%), this finding was not statistically significant (<i>P</i>=0.09). In glaucoma patients carrying GG genotype, mean linear C/D ratio was higher and progression was more compared to glaucoma patients with GT genotype.<b>CONCLUSION:</b> <i>APOE</i> -219 T>G polymorphism does not seem to be a risk factor for the presence of glaucoma, but might play a role in deterioration of the disease, which needs further evaluation.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067653/apolipoprotein Eprimary open angle glaucomapromotersingle nucleotide polymorphismsingle nucleotide polymorphism |
| spellingShingle | Emel Saglar Banu Bozkurt Murat Irkec Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population International Journal of Ophthalmology apolipoprotein E primary open angle glaucoma promoter single nucleotide polymorphism single nucleotide polymorphism |
| title | Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population |
| title_full | Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population |
| title_fullStr | Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population |
| title_full_unstemmed | Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population |
| title_short | Association of apolipoprotein E-219T>G promoter polymorphism with primary open angle glaucoma in Turkish population |
| title_sort | association of apolipoprotein e 219t gt g promoter polymorphism with primary open angle glaucoma in turkish population |
| topic | apolipoprotein E primary open angle glaucoma promoter single nucleotide polymorphism single nucleotide polymorphism |
| url | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067653/ |
| work_keys_str_mv | AT emelsaglar associationofapolipoproteine219tgtgpromoterpolymorphismwithprimaryopenangleglaucomainturkishpopulation AT banubozkurt associationofapolipoproteine219tgtgpromoterpolymorphismwithprimaryopenangleglaucomainturkishpopulation AT muratirkec associationofapolipoproteine219tgtgpromoterpolymorphismwithprimaryopenangleglaucomainturkishpopulation |