Short-Term PCB (Aroclor 1254) Toxicity on Few Phosphatases in Mice Brain
The present communication reports the dose and duration dependent toxicity of a PCB, Aroclor 1254, to a few ion dependent ATPases, Acid phosphatase, Alkaline phosphatase and Glucose-6-phosphatase in the whole brain tissue of mice. Two groups of mice were subjected to two sublethal doses (0.1 and 1 m...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2013-01-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.2203/dose-response.10-037.Kundu |
| _version_ | 1818840795356069888 |
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| author | Shweta Pathak Rahul Kundu |
| author_facet | Shweta Pathak Rahul Kundu |
| author_sort | Shweta Pathak |
| collection | DOAJ |
| description | The present communication reports the dose and duration dependent toxicity of a PCB, Aroclor 1254, to a few ion dependent ATPases, Acid phosphatase, Alkaline phosphatase and Glucose-6-phosphatase in the whole brain tissue of mice. Two groups of mice were subjected to two sublethal doses (0.1 and 1 mg kgbw −1 day −1 ) of PCB orally and exposed for 4, 8 or 12 days. A separate control group received the corn oil vehicle for the same exposure times. The observed results indicated exposure duration dependent changes in the enzymatic levels in the brain. The results suggest that the alteration in the enzymatic activity was possibly due to imposed oxidative stress generated by Aroclor 1254 on membrane-bound ion-dependent ATPases and other phosphatases in the brain tissue. |
| first_indexed | 2024-12-19T04:15:52Z |
| format | Article |
| id | doaj.art-ca81d2bde4564277985d46e6026ae5a7 |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-12-19T04:15:52Z |
| publishDate | 2013-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-ca81d2bde4564277985d46e6026ae5a72022-12-21T20:36:19ZengSAGE PublishingDose-Response1559-32582013-01-011110.2203/dose-response.10-037.KunduShort-Term PCB (Aroclor 1254) Toxicity on Few Phosphatases in Mice BrainShweta PathakRahul KunduThe present communication reports the dose and duration dependent toxicity of a PCB, Aroclor 1254, to a few ion dependent ATPases, Acid phosphatase, Alkaline phosphatase and Glucose-6-phosphatase in the whole brain tissue of mice. Two groups of mice were subjected to two sublethal doses (0.1 and 1 mg kgbw −1 day −1 ) of PCB orally and exposed for 4, 8 or 12 days. A separate control group received the corn oil vehicle for the same exposure times. The observed results indicated exposure duration dependent changes in the enzymatic levels in the brain. The results suggest that the alteration in the enzymatic activity was possibly due to imposed oxidative stress generated by Aroclor 1254 on membrane-bound ion-dependent ATPases and other phosphatases in the brain tissue.https://doi.org/10.2203/dose-response.10-037.Kundu |
| spellingShingle | Shweta Pathak Rahul Kundu Short-Term PCB (Aroclor 1254) Toxicity on Few Phosphatases in Mice Brain Dose-Response |
| title | Short-Term PCB (Aroclor 1254) Toxicity on Few Phosphatases in Mice Brain |
| title_full | Short-Term PCB (Aroclor 1254) Toxicity on Few Phosphatases in Mice Brain |
| title_fullStr | Short-Term PCB (Aroclor 1254) Toxicity on Few Phosphatases in Mice Brain |
| title_full_unstemmed | Short-Term PCB (Aroclor 1254) Toxicity on Few Phosphatases in Mice Brain |
| title_short | Short-Term PCB (Aroclor 1254) Toxicity on Few Phosphatases in Mice Brain |
| title_sort | short term pcb aroclor 1254 toxicity on few phosphatases in mice brain |
| url | https://doi.org/10.2203/dose-response.10-037.Kundu |
| work_keys_str_mv | AT shwetapathak shorttermpcbaroclor1254toxicityonfewphosphatasesinmicebrain AT rahulkundu shorttermpcbaroclor1254toxicityonfewphosphatasesinmicebrain |