Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects
Viruses are widespread in the environment, and many of them are major pathogens of serious plant, animal, and human diseases. The risk of pathogenicity, together with the capacity for constant mutation, emphasizes the need for measures to rapidly detect viruses. The need for highly sensitive bioanal...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/13/6/640 |
| _version_ | 1827738279370293248 |
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| author | Olga I. Guliy Stella S. Evstigneeva Vitaly A. Khanadeev Lev A. Dykman |
| author_facet | Olga I. Guliy Stella S. Evstigneeva Vitaly A. Khanadeev Lev A. Dykman |
| author_sort | Olga I. Guliy |
| collection | DOAJ |
| description | Viruses are widespread in the environment, and many of them are major pathogens of serious plant, animal, and human diseases. The risk of pathogenicity, together with the capacity for constant mutation, emphasizes the need for measures to rapidly detect viruses. The need for highly sensitive bioanalytical methods to diagnose and monitor socially significant viral diseases has increased in the past few years. This is due, on the one hand, to the increased incidence of viral diseases in general (including the unprecedented spread of a new coronavirus infection, SARS-CoV-2), and, on the other hand, to the need to overcome the limitations of modern biomedical diagnostic methods. Phage display technology antibodies as nano-bio-engineered macromolecules can be used for sensor-based virus detection. This review analyzes the commonly used virus detection methods and approaches and shows the prospects for the use of antibodies prepared by phage display technology as sensing elements for sensor-based virus detection. |
| first_indexed | 2024-03-11T02:42:10Z |
| format | Article |
| id | doaj.art-ca82ec02c4fd4fa79cdd1d5795f1aa3c |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-11T02:42:10Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-ca82ec02c4fd4fa79cdd1d5795f1aa3c2023-11-18T09:33:04ZengMDPI AGBiosensors2079-63742023-06-0113664010.3390/bios13060640Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future ProspectsOlga I. Guliy0Stella S. Evstigneeva1Vitaly A. Khanadeev2Lev A. Dykman3Institute of Biochemistry and Physiology of Plants and Microorganisms, Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), 13 Prospect Entuziastov, Saratov 410049, RussiaInstitute of Biochemistry and Physiology of Plants and Microorganisms, Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), 13 Prospect Entuziastov, Saratov 410049, RussiaInstitute of Biochemistry and Physiology of Plants and Microorganisms, Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), 13 Prospect Entuziastov, Saratov 410049, RussiaInstitute of Biochemistry and Physiology of Plants and Microorganisms, Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), 13 Prospect Entuziastov, Saratov 410049, RussiaViruses are widespread in the environment, and many of them are major pathogens of serious plant, animal, and human diseases. The risk of pathogenicity, together with the capacity for constant mutation, emphasizes the need for measures to rapidly detect viruses. The need for highly sensitive bioanalytical methods to diagnose and monitor socially significant viral diseases has increased in the past few years. This is due, on the one hand, to the increased incidence of viral diseases in general (including the unprecedented spread of a new coronavirus infection, SARS-CoV-2), and, on the other hand, to the need to overcome the limitations of modern biomedical diagnostic methods. Phage display technology antibodies as nano-bio-engineered macromolecules can be used for sensor-based virus detection. This review analyzes the commonly used virus detection methods and approaches and shows the prospects for the use of antibodies prepared by phage display technology as sensing elements for sensor-based virus detection.https://www.mdpi.com/2079-6374/13/6/640biosensorsvirusesdetection methodsantibody phage display technology |
| spellingShingle | Olga I. Guliy Stella S. Evstigneeva Vitaly A. Khanadeev Lev A. Dykman Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects Biosensors biosensors viruses detection methods antibody phage display technology |
| title | Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects |
| title_full | Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects |
| title_fullStr | Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects |
| title_full_unstemmed | Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects |
| title_short | Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects |
| title_sort | antibody phage display technology for sensor based virus detection current status and future prospects |
| topic | biosensors viruses detection methods antibody phage display technology |
| url | https://www.mdpi.com/2079-6374/13/6/640 |
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