Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H<sub>2</sub>DAB)[Co(H<sub>2</sub>PO<sub>3</sub>)<sub>4</sub>]·2H<sub>2</sub>O
A novel hybrid cobalt phosphite, (H<sub>2</sub>DAB)[Co(H<sub>2</sub>PO<sub>3</sub>)<sub>4</sub>] 2H<sub>2</sub>O, was synthesized by using a slow evaporation method in the presence of cobalt nitrate, phosphorous acid, and 1,4-diaminobutane...
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MDPI AG
2022-02-01
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| Online Access: | https://www.mdpi.com/2413-4155/4/1/5 |
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| author | Najlaa Hamdi Souad Chaouch Ivan da Silva Mohamed Ezahri Mohammed Lachkar Rama Alhasan Ahmad Yaman Abdin Claus Jacob Brahim El Bali |
| author_facet | Najlaa Hamdi Souad Chaouch Ivan da Silva Mohamed Ezahri Mohammed Lachkar Rama Alhasan Ahmad Yaman Abdin Claus Jacob Brahim El Bali |
| author_sort | Najlaa Hamdi |
| collection | DOAJ |
| description | A novel hybrid cobalt phosphite, (H<sub>2</sub>DAB)[Co(H<sub>2</sub>PO<sub>3</sub>)<sub>4</sub>] 2H<sub>2</sub>O, was synthesized by using a slow evaporation method in the presence of cobalt nitrate, phosphorous acid, and 1,4-diaminobutane (DAB = 1,4-diaminobutane) as a structure-directing agent. Single-crystal X-ray diffraction analysis showed that the compound crystallizes in the triclinic system (space group P-1(n.2)) with the following unit cell parameters (Å, °) a = 5.4814 (3), b = 7.5515 (4), c = 10.8548 (6), α = 88.001 (4), β = 88.707 (5), γ = 85.126 (5), and V = 447.33 (4) Å<sup>3</sup>. The crystal structure is built up from corner-sharing [CoO<sub>6</sub>] octahedra, forming chains parallel to [001], which are interconnected by H<sub>2</sub>PO<sub>3</sub><sup>−</sup> pseudo-tetrahedral units. The diprotonated cations, residing between the parallel chains, interact with the inorganic moiety via hydrogen bonds, thus leading to the formation of the 3D crystal structure. The Fourier transform infrared spectrum showed characteristic bands corresponding to the phosphite group and the organic amine. The thermal behavior of the compound mainly consisted of the loss of its organic moiety and the water molecules. The biological tests exhibited significant activity against <i>Candida albicans</i> and <i>Escherichia coli</i> strains at different concentrations, while less inhibitory activity was pronounced against <i>Staphylococcus epidermidis</i> and <i>Saccharomyces cerevisiae</i>, and in the case of multi-cellular organisms, no activity against the nematode model <i>Steinernema feltiae</i> was detected. |
| first_indexed | 2024-03-09T12:43:13Z |
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| institution | Directory Open Access Journal |
| issn | 2413-4155 |
| language | English |
| last_indexed | 2024-03-09T12:43:13Z |
| publishDate | 2022-02-01 |
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| spelling | doaj.art-ca851e57b18f44bfb904b749be97a34d2023-11-30T22:15:32ZengMDPI AGSci2413-41552022-02-0141510.3390/sci4010005Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H<sub>2</sub>DAB)[Co(H<sub>2</sub>PO<sub>3</sub>)<sub>4</sub>]·2H<sub>2</sub>ONajlaa Hamdi0Souad Chaouch1Ivan da Silva2Mohamed Ezahri3Mohammed Lachkar4Rama Alhasan5Ahmad Yaman Abdin6Claus Jacob7Brahim El Bali8Engineering Laboratory of Organometallic Molecular Materials and Environment, Faculty of Sciences, University Sidi Mohamed Ben Abdellah, Fez 30000, MoroccoEngineering Laboratory of Organometallic Molecular Materials and Environment, Faculty of Sciences, University Sidi Mohamed Ben Abdellah, Fez 30000, MoroccoISIS Facility, STFC Rutherford Appleton Laboratory, Chilton, Oxfordshire OX11 0QX, UKLaboratoire Matériaux et Environnement, Faculté des Sciences, Université Ibn Zohr, Agadir 80000, MoroccoEngineering Laboratory of Organometallic Molecular Materials and Environment, Faculty of Sciences, University Sidi Mohamed Ben Abdellah, Fez 30000, MoroccoDivision of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, GermanyDivision of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, GermanyDivision of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, GermanyEngineering Laboratory of Organometallic Molecular Materials and Environment, Faculty of Sciences, University Sidi Mohamed Ben Abdellah, Fez 30000, MoroccoA novel hybrid cobalt phosphite, (H<sub>2</sub>DAB)[Co(H<sub>2</sub>PO<sub>3</sub>)<sub>4</sub>] 2H<sub>2</sub>O, was synthesized by using a slow evaporation method in the presence of cobalt nitrate, phosphorous acid, and 1,4-diaminobutane (DAB = 1,4-diaminobutane) as a structure-directing agent. Single-crystal X-ray diffraction analysis showed that the compound crystallizes in the triclinic system (space group P-1(n.2)) with the following unit cell parameters (Å, °) a = 5.4814 (3), b = 7.5515 (4), c = 10.8548 (6), α = 88.001 (4), β = 88.707 (5), γ = 85.126 (5), and V = 447.33 (4) Å<sup>3</sup>. The crystal structure is built up from corner-sharing [CoO<sub>6</sub>] octahedra, forming chains parallel to [001], which are interconnected by H<sub>2</sub>PO<sub>3</sub><sup>−</sup> pseudo-tetrahedral units. The diprotonated cations, residing between the parallel chains, interact with the inorganic moiety via hydrogen bonds, thus leading to the formation of the 3D crystal structure. The Fourier transform infrared spectrum showed characteristic bands corresponding to the phosphite group and the organic amine. The thermal behavior of the compound mainly consisted of the loss of its organic moiety and the water molecules. The biological tests exhibited significant activity against <i>Candida albicans</i> and <i>Escherichia coli</i> strains at different concentrations, while less inhibitory activity was pronounced against <i>Staphylococcus epidermidis</i> and <i>Saccharomyces cerevisiae</i>, and in the case of multi-cellular organisms, no activity against the nematode model <i>Steinernema feltiae</i> was detected.https://www.mdpi.com/2413-4155/4/1/5hybrid phosphiteX-ray crystal structureFTIRthermal behaviorbiological activitiesantimicrobial |
| spellingShingle | Najlaa Hamdi Souad Chaouch Ivan da Silva Mohamed Ezahri Mohammed Lachkar Rama Alhasan Ahmad Yaman Abdin Claus Jacob Brahim El Bali Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H<sub>2</sub>DAB)[Co(H<sub>2</sub>PO<sub>3</sub>)<sub>4</sub>]·2H<sub>2</sub>O Sci hybrid phosphite X-ray crystal structure FTIR thermal behavior biological activities antimicrobial |
| title | Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H<sub>2</sub>DAB)[Co(H<sub>2</sub>PO<sub>3</sub>)<sub>4</sub>]·2H<sub>2</sub>O |
| title_full | Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H<sub>2</sub>DAB)[Co(H<sub>2</sub>PO<sub>3</sub>)<sub>4</sub>]·2H<sub>2</sub>O |
| title_fullStr | Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H<sub>2</sub>DAB)[Co(H<sub>2</sub>PO<sub>3</sub>)<sub>4</sub>]·2H<sub>2</sub>O |
| title_full_unstemmed | Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H<sub>2</sub>DAB)[Co(H<sub>2</sub>PO<sub>3</sub>)<sub>4</sub>]·2H<sub>2</sub>O |
| title_short | Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H<sub>2</sub>DAB)[Co(H<sub>2</sub>PO<sub>3</sub>)<sub>4</sub>]·2H<sub>2</sub>O |
| title_sort | synthesis structural characterization and biological activities of organically templated cobalt phosphite h sub 2 sub dab co h sub 2 sub po sub 3 sub sub 4 sub ·2h sub 2 sub o |
| topic | hybrid phosphite X-ray crystal structure FTIR thermal behavior biological activities antimicrobial |
| url | https://www.mdpi.com/2413-4155/4/1/5 |
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