Vertebrate cardiac regeneration: evolutionary and developmental perspectives
Abstract Cardiac regeneration is an ancestral trait in vertebrates that is lost both as more recent vertebrate lineages evolved to adapt to new environments and selective pressures, and as members of certain species developmentally progress towards their adult forms. While higher vertebrates like hu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-03-01
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| Series: | Cell Regeneration |
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| Online Access: | https://doi.org/10.1186/s13619-020-00068-y |
| _version_ | 1818915401667444736 |
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| author | Stephen Cutie Guo N. Huang |
| author_facet | Stephen Cutie Guo N. Huang |
| author_sort | Stephen Cutie |
| collection | DOAJ |
| description | Abstract Cardiac regeneration is an ancestral trait in vertebrates that is lost both as more recent vertebrate lineages evolved to adapt to new environments and selective pressures, and as members of certain species developmentally progress towards their adult forms. While higher vertebrates like humans and rodents resolve cardiac injury with permanent fibrosis and loss of cardiac output as adults, neonates of these same species can fully regenerate heart structure and function after injury – as can adult lower vertebrates like many teleost fish and urodele amphibians. Recent research has elucidated several broad factors hypothesized to contribute to this loss of cardiac regenerative potential both evolutionarily and developmentally: an oxygen-rich environment, vertebrate thermogenesis, a complex adaptive immune system, and cancer risk trade-offs. In this review, we discuss the evidence for these hypotheses as well as the cellular participators and molecular regulators by which they act to govern heart regeneration in vertebrates. |
| first_indexed | 2024-12-20T00:01:42Z |
| format | Article |
| id | doaj.art-ca87f97f10434ad2b97c470518c8ac6c |
| institution | Directory Open Access Journal |
| issn | 2045-9769 |
| language | English |
| last_indexed | 2024-12-20T00:01:42Z |
| publishDate | 2021-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Cell Regeneration |
| spelling | doaj.art-ca87f97f10434ad2b97c470518c8ac6c2022-12-21T20:00:49ZengSpringerOpenCell Regeneration2045-97692021-03-0110111010.1186/s13619-020-00068-yVertebrate cardiac regeneration: evolutionary and developmental perspectivesStephen Cutie0Guo N. Huang1Cardiovascular Research Institute and Department of Physiology, University of CaliforniaCardiovascular Research Institute and Department of Physiology, University of CaliforniaAbstract Cardiac regeneration is an ancestral trait in vertebrates that is lost both as more recent vertebrate lineages evolved to adapt to new environments and selective pressures, and as members of certain species developmentally progress towards their adult forms. While higher vertebrates like humans and rodents resolve cardiac injury with permanent fibrosis and loss of cardiac output as adults, neonates of these same species can fully regenerate heart structure and function after injury – as can adult lower vertebrates like many teleost fish and urodele amphibians. Recent research has elucidated several broad factors hypothesized to contribute to this loss of cardiac regenerative potential both evolutionarily and developmentally: an oxygen-rich environment, vertebrate thermogenesis, a complex adaptive immune system, and cancer risk trade-offs. In this review, we discuss the evidence for these hypotheses as well as the cellular participators and molecular regulators by which they act to govern heart regeneration in vertebrates.https://doi.org/10.1186/s13619-020-00068-yHeartRegenerationDevelopmentEvolutionCardiomyocyte proliferationCell cycle arrest |
| spellingShingle | Stephen Cutie Guo N. Huang Vertebrate cardiac regeneration: evolutionary and developmental perspectives Cell Regeneration Heart Regeneration Development Evolution Cardiomyocyte proliferation Cell cycle arrest |
| title | Vertebrate cardiac regeneration: evolutionary and developmental perspectives |
| title_full | Vertebrate cardiac regeneration: evolutionary and developmental perspectives |
| title_fullStr | Vertebrate cardiac regeneration: evolutionary and developmental perspectives |
| title_full_unstemmed | Vertebrate cardiac regeneration: evolutionary and developmental perspectives |
| title_short | Vertebrate cardiac regeneration: evolutionary and developmental perspectives |
| title_sort | vertebrate cardiac regeneration evolutionary and developmental perspectives |
| topic | Heart Regeneration Development Evolution Cardiomyocyte proliferation Cell cycle arrest |
| url | https://doi.org/10.1186/s13619-020-00068-y |
| work_keys_str_mv | AT stephencutie vertebratecardiacregenerationevolutionaryanddevelopmentalperspectives AT guonhuang vertebratecardiacregenerationevolutionaryanddevelopmentalperspectives |