Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease. Infections or infectious reactivation are potential triggers for initiation of autoimmunity and for SLE flares. Epstein-Barr virus (EBV) is gamma herpes virus that has been associated with several autoimmune diseases such a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.623944/full |
| _version_ | 1818390064245243904 |
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| author | Neelakshi R. Jog Judith A. James Judith A. James |
| author_facet | Neelakshi R. Jog Judith A. James Judith A. James |
| author_sort | Neelakshi R. Jog |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease. Infections or infectious reactivation are potential triggers for initiation of autoimmunity and for SLE flares. Epstein-Barr virus (EBV) is gamma herpes virus that has been associated with several autoimmune diseases such as SLE, multiple sclerosis, Sjogren’s syndrome, and systemic sclerosis. In this review, we will discuss the recent advances regarding how EBV may contribute to immune dysregulation, and how these mechanisms may relate to SLE disease progression. |
| first_indexed | 2024-12-14T04:51:41Z |
| format | Article |
| id | doaj.art-ca88327e116740acac426103bc7d0b39 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T04:51:41Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ca88327e116740acac426103bc7d0b392022-12-21T23:16:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-02-011110.3389/fimmu.2020.623944623944Epstein Barr Virus and Autoimmune Responses in Systemic Lupus ErythematosusNeelakshi R. Jog0Judith A. James1Judith A. James2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United StatesArthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United StatesDepartments of Medicine, Pathology, Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesSystemic lupus erythematosus (SLE) is a complex systemic autoimmune disease. Infections or infectious reactivation are potential triggers for initiation of autoimmunity and for SLE flares. Epstein-Barr virus (EBV) is gamma herpes virus that has been associated with several autoimmune diseases such as SLE, multiple sclerosis, Sjogren’s syndrome, and systemic sclerosis. In this review, we will discuss the recent advances regarding how EBV may contribute to immune dysregulation, and how these mechanisms may relate to SLE disease progression.https://www.frontiersin.org/articles/10.3389/fimmu.2020.623944/fullEpstein-Barr virussystemic lupus erythematosusinflammationautoimmune diseaseviral homologs of host genesmolecular mimicry |
| spellingShingle | Neelakshi R. Jog Judith A. James Judith A. James Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus Frontiers in Immunology Epstein-Barr virus systemic lupus erythematosus inflammation autoimmune disease viral homologs of host genes molecular mimicry |
| title | Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus |
| title_full | Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus |
| title_fullStr | Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus |
| title_full_unstemmed | Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus |
| title_short | Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus |
| title_sort | epstein barr virus and autoimmune responses in systemic lupus erythematosus |
| topic | Epstein-Barr virus systemic lupus erythematosus inflammation autoimmune disease viral homologs of host genes molecular mimicry |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.623944/full |
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