Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons

Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons

Abstract Background Cell replacement therapy has been envisioned as a promising treatment for neurodegenerative diseases. Due to the ethical concerns of ESCs-derived neural progenitor cells (NPCs) and tumorigenic potential of iPSCs, reprogramming of somatic cells directly into multipotent NPCs has e...

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Bibliographic Details
Main Authors: Kangmu Ma, Xiaobei Deng, Xiaohuan Xia, Zhaohuan Fan, Xinrui Qi, Yongxiang Wang, Yuju Li, Yizhao Ma, Qiang Chen, Hui Peng, Jianqing Ding, Chunhong Li, Yunlong Huang, Changhai Tian, Jialin C. Zheng
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Translational Neurodegeneration
Subjects:
Astrocytes
iNPCs
Reprogramming
Transcription factor
Neuronal lineage
Cholinergic neurons
Online Access:http://link.springer.com/article/10.1186/s40035-018-0132-x

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http://link.springer.com/article/10.1186/s40035-018-0132-x

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