Oxygen Limitation Enhances the Antimicrobial Activity of Fosfomycin in Pseudomonas aeruginosa Following Overexpression of glpT Which Encodes Glycerol-3-Phosphate/Fosfomycin Symporter

Oxygen Limitation Enhances the Antimicrobial Activity of Fosfomycin in Pseudomonas aeruginosa Following Overexpression of glpT Which Encodes Glycerol-3-Phosphate/Fosfomycin Symporter

Fosfomycin is resurfacing as a “last resort drug” to treat infections caused by multidrug resistant pathogens. This drug has a remarkable benefit in that its activity increases under oxygen-limited conditions unlike other commonly used antimicrobials such as β-lactams, fluoroquinolones and aminoglyc...

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Bibliographic Details
Main Authors: Hidetada Hirakawa, Kumiko Kurabayashi, Koichi Tanimoto, Haruyoshi Tomita
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Microbiology
Subjects:
antimicrobial resistance (AMR)
multi-drug resistance (MDR)
fosfomycin
anaerobiosis
cystic fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01950/full

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