Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation

Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation

We previously reported that measles virus nucleocapsid protein (MVNP) expression in osteoclasts (OCLs) of patients with Paget disease (PD) or targeted to the OCL lineage in MVNP-transgenic mice (MVNP mice) increases IGF1 production in osteoclasts (OCL-IGF1) and leads to development of PD OCLs and pa...

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Bibliographic Details
Main Authors: Kazuaki Miyagawa, Hirofumi Tenshin, Patrick L. Mulcrone, Jesus Delgado-Calle, Mark A. Subler, Jolene J. Windle, John M. Chirgwin, G. David Roodman, Noriyoshi Kurihara
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-07-01
Series:JCI Insight
Subjects:
Bone biology
Endocrinology
Online Access:https://doi.org/10.1172/jci.insight.159838

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