In the Body's Eye: The computational anatomy of interoceptive inference.
A growing body of evidence highlights the intricate linkage of exteroceptive perception to the rhythmic activity of the visceral body. In parallel, interoceptive inference theories of affective perception and self-consciousness are on the rise in cognitive science. However, thus far no formal theory...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-09-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1010490 |
| _version_ | 1797996798930845696 |
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| author | Micah Allen Andrew Levy Thomas Parr Karl J Friston |
| author_facet | Micah Allen Andrew Levy Thomas Parr Karl J Friston |
| author_sort | Micah Allen |
| collection | DOAJ |
| description | A growing body of evidence highlights the intricate linkage of exteroceptive perception to the rhythmic activity of the visceral body. In parallel, interoceptive inference theories of affective perception and self-consciousness are on the rise in cognitive science. However, thus far no formal theory has emerged to integrate these twin domains; instead, most extant work is conceptual in nature. Here, we introduce a formal model of cardiac active inference, which explains how ascending cardiac signals entrain exteroceptive sensory perception and uncertainty. Through simulated psychophysics, we reproduce the defensive startle reflex and commonly reported effects linking the cardiac cycle to affective behaviour. We further show that simulated 'interoceptive lesions' blunt affective expectations, induce psychosomatic hallucinations, and exacerbate biases in perceptual uncertainty. Through synthetic heart-rate variability analyses, we illustrate how the balance of arousal-priors and visceral prediction errors produces idiosyncratic patterns of physiological reactivity. Our model thus offers a roadmap for computationally phenotyping disordered brain-body interaction. |
| first_indexed | 2024-04-11T10:23:03Z |
| format | Article |
| id | doaj.art-ca8afb2dbecb44e79b1e300a56d54570 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-04-11T10:23:03Z |
| publishDate | 2022-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-ca8afb2dbecb44e79b1e300a56d545702022-12-22T04:29:41ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582022-09-01189e101049010.1371/journal.pcbi.1010490In the Body's Eye: The computational anatomy of interoceptive inference.Micah AllenAndrew LevyThomas ParrKarl J FristonA growing body of evidence highlights the intricate linkage of exteroceptive perception to the rhythmic activity of the visceral body. In parallel, interoceptive inference theories of affective perception and self-consciousness are on the rise in cognitive science. However, thus far no formal theory has emerged to integrate these twin domains; instead, most extant work is conceptual in nature. Here, we introduce a formal model of cardiac active inference, which explains how ascending cardiac signals entrain exteroceptive sensory perception and uncertainty. Through simulated psychophysics, we reproduce the defensive startle reflex and commonly reported effects linking the cardiac cycle to affective behaviour. We further show that simulated 'interoceptive lesions' blunt affective expectations, induce psychosomatic hallucinations, and exacerbate biases in perceptual uncertainty. Through synthetic heart-rate variability analyses, we illustrate how the balance of arousal-priors and visceral prediction errors produces idiosyncratic patterns of physiological reactivity. Our model thus offers a roadmap for computationally phenotyping disordered brain-body interaction.https://doi.org/10.1371/journal.pcbi.1010490 |
| spellingShingle | Micah Allen Andrew Levy Thomas Parr Karl J Friston In the Body's Eye: The computational anatomy of interoceptive inference. PLoS Computational Biology |
| title | In the Body's Eye: The computational anatomy of interoceptive inference. |
| title_full | In the Body's Eye: The computational anatomy of interoceptive inference. |
| title_fullStr | In the Body's Eye: The computational anatomy of interoceptive inference. |
| title_full_unstemmed | In the Body's Eye: The computational anatomy of interoceptive inference. |
| title_short | In the Body's Eye: The computational anatomy of interoceptive inference. |
| title_sort | in the body s eye the computational anatomy of interoceptive inference |
| url | https://doi.org/10.1371/journal.pcbi.1010490 |
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