Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men
Large population-based studies investigating the association of physical activity (PA) with the metabolite signature contribute significantly to the understanding of the effects of PA on metabolic pathways associated with the risk of type2 diabetes. Our study included 8749 Finnish men without diabet...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/1/69 |
| _version_ | 1797492053541650432 |
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| author | Susanna Maria Kemppainen Lilian Fernandes Silva Maria Anneli Lankinen Ursula Schwab Markku Laakso |
| author_facet | Susanna Maria Kemppainen Lilian Fernandes Silva Maria Anneli Lankinen Ursula Schwab Markku Laakso |
| author_sort | Susanna Maria Kemppainen |
| collection | DOAJ |
| description | Large population-based studies investigating the association of physical activity (PA) with the metabolite signature contribute significantly to the understanding of the effects of PA on metabolic pathways associated with the risk of type2 diabetes. Our study included 8749 Finnish men without diabetes at baseline recruited from the Metabolic Syndrome in Men (METSIM) cohort. We used a questionnaire to measure leisure-time PA. Metabolites were measured in 7271 men as a part of Metabolon’s untargeted Discovery HD4 platform using ultrahigh-performance liquid chromatography–tandem mass spectrometry. We found 198 metabolites significantly associated with PA. Several of these metabolites were novel including especially steroids, amino acids, imidazoles, carboxylic acids, and hydroxy acids. Increased PA was significantly associated with high levels of choline plasmalogens, lysophosphatidylcholines, polyunsaturated fatty acids, carotenoids, long chain acylcarnitines, imidazoles, bilirubins, aryl sulfates, hydroxy acids, indolepropionate, and indolelactate. Several of these metabolites have been previously associated with a decreased risk of type 2 diabetes and with a healthy diet. Our population-based study shows that the metabolite signature of increased PA includes multiple metabolic pathways and is associated with better adherence to a healthy lifestyle. |
| first_indexed | 2024-03-10T00:58:03Z |
| format | Article |
| id | doaj.art-ca8c9ad9a59142cca7497bdc0793d1d4 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T00:58:03Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-ca8c9ad9a59142cca7497bdc0793d1d42023-11-23T14:40:30ZengMDPI AGMetabolites2218-19892022-01-011216910.3390/metabo12010069Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 MenSusanna Maria Kemppainen0Lilian Fernandes Silva1Maria Anneli Lankinen2Ursula Schwab3Markku Laakso4Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70210 Kuopio, FinlandInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, FinlandInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, 70210 Kuopio, FinlandInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, 70210 Kuopio, FinlandInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, FinlandLarge population-based studies investigating the association of physical activity (PA) with the metabolite signature contribute significantly to the understanding of the effects of PA on metabolic pathways associated with the risk of type2 diabetes. Our study included 8749 Finnish men without diabetes at baseline recruited from the Metabolic Syndrome in Men (METSIM) cohort. We used a questionnaire to measure leisure-time PA. Metabolites were measured in 7271 men as a part of Metabolon’s untargeted Discovery HD4 platform using ultrahigh-performance liquid chromatography–tandem mass spectrometry. We found 198 metabolites significantly associated with PA. Several of these metabolites were novel including especially steroids, amino acids, imidazoles, carboxylic acids, and hydroxy acids. Increased PA was significantly associated with high levels of choline plasmalogens, lysophosphatidylcholines, polyunsaturated fatty acids, carotenoids, long chain acylcarnitines, imidazoles, bilirubins, aryl sulfates, hydroxy acids, indolepropionate, and indolelactate. Several of these metabolites have been previously associated with a decreased risk of type 2 diabetes and with a healthy diet. Our population-based study shows that the metabolite signature of increased PA includes multiple metabolic pathways and is associated with better adherence to a healthy lifestyle.https://www.mdpi.com/2218-1989/12/1/69physical activitytype 2 diabetesinsulin sensitivityinsulin secretionmetaboliteshealthy diet |
| spellingShingle | Susanna Maria Kemppainen Lilian Fernandes Silva Maria Anneli Lankinen Ursula Schwab Markku Laakso Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men Metabolites physical activity type 2 diabetes insulin sensitivity insulin secretion metabolites healthy diet |
| title | Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men |
| title_full | Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men |
| title_fullStr | Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men |
| title_full_unstemmed | Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men |
| title_short | Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men |
| title_sort | metabolite signature of physical activity and the risk of type 2 diabetes in 7271 men |
| topic | physical activity type 2 diabetes insulin sensitivity insulin secretion metabolites healthy diet |
| url | https://www.mdpi.com/2218-1989/12/1/69 |
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