Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF
Heart failure (HF) is a chronic and progressive syndrome affecting worldwide billions of patients. Exercise intolerance and early fatigue are hallmarks of HF patients either with a reduced (HFrEF) or a preserved (HFpEF) ejection fraction. Alterations of the skeletal muscle contribute to exercise int...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1149065/full |
| _version_ | 1797647983610691584 |
|---|---|
| author | Norman Mangner Ephraim B. Winzer Axel Linke Volker Adams Volker Adams |
| author_facet | Norman Mangner Ephraim B. Winzer Axel Linke Volker Adams Volker Adams |
| author_sort | Norman Mangner |
| collection | DOAJ |
| description | Heart failure (HF) is a chronic and progressive syndrome affecting worldwide billions of patients. Exercise intolerance and early fatigue are hallmarks of HF patients either with a reduced (HFrEF) or a preserved (HFpEF) ejection fraction. Alterations of the skeletal muscle contribute to exercise intolerance in HF. This review will provide a contemporary summary of the clinical and molecular alterations currently known to occur in the skeletal muscles of both HFrEF and HFpEF, and thereby differentiate the effects on locomotor and respiratory muscles, in particular the diaphragm. Moreover, current and future therapeutic options to address skeletal muscle weakness will be discussed focusing mainly on the effects of exercise training. |
| first_indexed | 2024-03-11T15:25:31Z |
| format | Article |
| id | doaj.art-ca8dc5f4140e4d15bab514de237a25e3 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-11T15:25:31Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-ca8dc5f4140e4d15bab514de237a25e32023-10-27T22:19:14ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-10-011010.3389/fcvm.2023.11490651149065Locomotor and respiratory muscle abnormalities in HFrEF and HFpEFNorman Mangner0Ephraim B. Winzer1Axel Linke2Volker Adams3Volker Adams4Department of Internal Medicine and Cardiology, Heart Center Dresden, Technische Universität Dresden, Dresden, GermanyDepartment of Internal Medicine and Cardiology, Heart Center Dresden, Technische Universität Dresden, Dresden, GermanyDepartment of Internal Medicine and Cardiology, Heart Center Dresden, Technische Universität Dresden, Dresden, GermanyLaboratory of Molecular and Experimental Cardiology, Heart Center Dresden, Technische Universität Dresden, Dresden, GermanyDresden Cardiovascular Research Institute and Core Laboratories GmbH, Dresden, GermanyHeart failure (HF) is a chronic and progressive syndrome affecting worldwide billions of patients. Exercise intolerance and early fatigue are hallmarks of HF patients either with a reduced (HFrEF) or a preserved (HFpEF) ejection fraction. Alterations of the skeletal muscle contribute to exercise intolerance in HF. This review will provide a contemporary summary of the clinical and molecular alterations currently known to occur in the skeletal muscles of both HFrEF and HFpEF, and thereby differentiate the effects on locomotor and respiratory muscles, in particular the diaphragm. Moreover, current and future therapeutic options to address skeletal muscle weakness will be discussed focusing mainly on the effects of exercise training.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1149065/fullHFrEFHFpEFskeletal musclediaphragmsarcopeniacachexia |
| spellingShingle | Norman Mangner Ephraim B. Winzer Axel Linke Volker Adams Volker Adams Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF Frontiers in Cardiovascular Medicine HFrEF HFpEF skeletal muscle diaphragm sarcopenia cachexia |
| title | Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF |
| title_full | Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF |
| title_fullStr | Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF |
| title_full_unstemmed | Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF |
| title_short | Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF |
| title_sort | locomotor and respiratory muscle abnormalities in hfref and hfpef |
| topic | HFrEF HFpEF skeletal muscle diaphragm sarcopenia cachexia |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1149065/full |
| work_keys_str_mv | AT normanmangner locomotorandrespiratorymuscleabnormalitiesinhfrefandhfpef AT ephraimbwinzer locomotorandrespiratorymuscleabnormalitiesinhfrefandhfpef AT axellinke locomotorandrespiratorymuscleabnormalitiesinhfrefandhfpef AT volkeradams locomotorandrespiratorymuscleabnormalitiesinhfrefandhfpef AT volkeradams locomotorandrespiratorymuscleabnormalitiesinhfrefandhfpef |