Statins as potential therapeutic drug for asthma?
<p>Abstract</p> <p>Background</p> <p>Statins are lipid-lowering agents that also exhibit pleiotropic effects in decreasing oxidative stress and inflammation. There have been several published studies reporting the use of statins in the treatment of asthma patients, but...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-11-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://respiratory-research.com/content/13/1/108 |
| _version_ | 1831569074730041344 |
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| author | Yuan Cheng Zhou Lin Cheng Jiyun Zhang Jingying Teng Yue Huang Mao Adcock Ian M Barnes Peter J Yao Xin |
| author_facet | Yuan Cheng Zhou Lin Cheng Jiyun Zhang Jingying Teng Yue Huang Mao Adcock Ian M Barnes Peter J Yao Xin |
| author_sort | Yuan Cheng |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Statins are lipid-lowering agents that also exhibit pleiotropic effects in decreasing oxidative stress and inflammation. There have been several published studies reporting the use of statins in the treatment of asthma patients, but their results are not consistent. The aim of this study is to determine whether statins are beneficial for asthma administration, and explore the potential covariables that may affect their clinical effectiveness.</p> <p>Methods</p> <p>A systematic literature search was performed in PubMed, Embase and Cochrane Center Register of Controlled Trials from inception to September 2012. Randomized controlled trials (RCT), retrospective studies and controlled clinical trials which reported the use of statins in the treatment of asthma patients were eligible. Quality evaluation was conducted for RCT using Jadad criteria.</p> <p>Results</p> <p>A total of 18 articles were included. In our study, we found no conclusive evidence to demonstrate that statins could enhance the lung function in asthmatics, although, they may reduce airway inflammation. Additionally, the results were not consistent across studies with respect to symptoms, quality of life, maintenance medication, asthma hospitalization/emergency department (ED) visits.</p> <p>Conclusions</p> <p>Statins may reduce airway inflammation in asthmatics, without having a significant effect on lung function. Further large sample and multicenter clinical trials are needed to confirm this and to see if there are more responsive phenotypes of asthma.</p> |
| first_indexed | 2024-12-17T12:25:58Z |
| format | Article |
| id | doaj.art-ca8ddd28d95349dd8041355bc3d9170c |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-17T12:25:58Z |
| publishDate | 2012-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-ca8ddd28d95349dd8041355bc3d9170c2022-12-21T21:48:45ZengBMCRespiratory Research1465-99212012-11-0113110810.1186/1465-9921-13-108Statins as potential therapeutic drug for asthma?Yuan ChengZhou LinCheng JiyunZhang JingyingTeng YueHuang MaoAdcock Ian MBarnes Peter JYao Xin<p>Abstract</p> <p>Background</p> <p>Statins are lipid-lowering agents that also exhibit pleiotropic effects in decreasing oxidative stress and inflammation. There have been several published studies reporting the use of statins in the treatment of asthma patients, but their results are not consistent. The aim of this study is to determine whether statins are beneficial for asthma administration, and explore the potential covariables that may affect their clinical effectiveness.</p> <p>Methods</p> <p>A systematic literature search was performed in PubMed, Embase and Cochrane Center Register of Controlled Trials from inception to September 2012. Randomized controlled trials (RCT), retrospective studies and controlled clinical trials which reported the use of statins in the treatment of asthma patients were eligible. Quality evaluation was conducted for RCT using Jadad criteria.</p> <p>Results</p> <p>A total of 18 articles were included. In our study, we found no conclusive evidence to demonstrate that statins could enhance the lung function in asthmatics, although, they may reduce airway inflammation. Additionally, the results were not consistent across studies with respect to symptoms, quality of life, maintenance medication, asthma hospitalization/emergency department (ED) visits.</p> <p>Conclusions</p> <p>Statins may reduce airway inflammation in asthmatics, without having a significant effect on lung function. Further large sample and multicenter clinical trials are needed to confirm this and to see if there are more responsive phenotypes of asthma.</p>http://respiratory-research.com/content/13/1/108StatinsAsthmaAnti-inflammatoryLung function |
| spellingShingle | Yuan Cheng Zhou Lin Cheng Jiyun Zhang Jingying Teng Yue Huang Mao Adcock Ian M Barnes Peter J Yao Xin Statins as potential therapeutic drug for asthma? Respiratory Research Statins Asthma Anti-inflammatory Lung function |
| title | Statins as potential therapeutic drug for asthma? |
| title_full | Statins as potential therapeutic drug for asthma? |
| title_fullStr | Statins as potential therapeutic drug for asthma? |
| title_full_unstemmed | Statins as potential therapeutic drug for asthma? |
| title_short | Statins as potential therapeutic drug for asthma? |
| title_sort | statins as potential therapeutic drug for asthma |
| topic | Statins Asthma Anti-inflammatory Lung function |
| url | http://respiratory-research.com/content/13/1/108 |
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