Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease
Abstract Background: Zataria multiflora Boiss is a well-known medicinal plant and its’ essential oil (EO) is traditionally used for treatment of respiratory and digestive disorders and/or bacterial, viral, fungal, and parasitic infections. Objective: This study was undertaken to evaluate the effect...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2020-03-01
|
| Series: | Iranian Journal of Colorectal Research |
| Subjects: | |
| Online Access: | https://colorectalresearch.sums.ac.ir/article_46473_6fedafc1d0ba4decb42d9375ed7f2a37.pdf |
| _version_ | 1828381696314048512 |
|---|---|
| author | Arash Jafari Mohammad Moazeni Seyed Vahid Hosseini Hajar Khazraei Samane Nematolahi Seyed Mohammad Kazem Tadayon |
| author_facet | Arash Jafari Mohammad Moazeni Seyed Vahid Hosseini Hajar Khazraei Samane Nematolahi Seyed Mohammad Kazem Tadayon |
| author_sort | Arash Jafari |
| collection | DOAJ |
| description | Abstract Background: Zataria multiflora Boiss is a well-known medicinal plant and its’ essential oil (EO) is traditionally used for treatment of respiratory and digestive disorders and/or bacterial, viral, fungal, and parasitic infections. Objective: This study was undertaken to evaluate the effect of long-term consumption of Z. multiflora EO on hematological and biochemical parameters in patients infected with liver hydatid disease. Materials and Methods: Fifteen patients were administered orally with Z. multiflora EO (60 mg daily) for six months. Hematological and biochemical analysis were performed on the blood samples of patients before the start of treatment and after completion of the treatment course. In hematological analysis, WBC, RBC, Hb, hematocrit, MCV, MCH, MCHC and platelets were measured. In biochemical analysis, FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, K, Cl, AST, ALT, and ALK were assessed. Results: No apparent changes were observed in the values of hematological parameters of the patients after treatment. No significant changes also occurred in the values of FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, and K. The mean values of AST, ALT and ALK enzymes decreased significantly after treatment (P ˂ 0.05). No adverse clinical event was noticed in the patients during the course of study. Conclusions: Long-term consumption of Z. multiflora EO induced no adverse effect on the hematological and biochemical parameters of patients infected with liver hydatid disease. Since Z. multiflora EO reduced the level of liver transaminases (AST, ALT and ALK), this herbal product may be considered as a hepatoprotective agent in human beings. |
| first_indexed | 2024-12-10T04:19:38Z |
| format | Article |
| id | doaj.art-ca8e62a9c7e342c3a8ef3f38c623b4cb |
| institution | Directory Open Access Journal |
| issn | 2783-2430 |
| language | English |
| last_indexed | 2024-12-10T04:19:38Z |
| publishDate | 2020-03-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Colorectal Research |
| spelling | doaj.art-ca8e62a9c7e342c3a8ef3f38c623b4cb2022-12-22T02:02:28ZengShiraz University of Medical SciencesIranian Journal of Colorectal Research2783-24302020-03-0181172210.30476/acrr.2020.4647346473Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid diseaseArash Jafari0Mohammad Moazeni1Seyed Vahid Hosseini2Hajar Khazraei3Samane Nematolahi4Seyed Mohammad Kazem Tadayon5School of Veterinary Medicine, Shiraz University, Shiraz, IranDepartment of Pathobilogy, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IranColorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR IranDepartment of biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Colorectal Research Center Shiraz University of Medical Sciences Shiraz IranAbstract Background: Zataria multiflora Boiss is a well-known medicinal plant and its’ essential oil (EO) is traditionally used for treatment of respiratory and digestive disorders and/or bacterial, viral, fungal, and parasitic infections. Objective: This study was undertaken to evaluate the effect of long-term consumption of Z. multiflora EO on hematological and biochemical parameters in patients infected with liver hydatid disease. Materials and Methods: Fifteen patients were administered orally with Z. multiflora EO (60 mg daily) for six months. Hematological and biochemical analysis were performed on the blood samples of patients before the start of treatment and after completion of the treatment course. In hematological analysis, WBC, RBC, Hb, hematocrit, MCV, MCH, MCHC and platelets were measured. In biochemical analysis, FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, K, Cl, AST, ALT, and ALK were assessed. Results: No apparent changes were observed in the values of hematological parameters of the patients after treatment. No significant changes also occurred in the values of FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, and K. The mean values of AST, ALT and ALK enzymes decreased significantly after treatment (P ˂ 0.05). No adverse clinical event was noticed in the patients during the course of study. Conclusions: Long-term consumption of Z. multiflora EO induced no adverse effect on the hematological and biochemical parameters of patients infected with liver hydatid disease. Since Z. multiflora EO reduced the level of liver transaminases (AST, ALT and ALK), this herbal product may be considered as a hepatoprotective agent in human beings.https://colorectalresearch.sums.ac.ir/article_46473_6fedafc1d0ba4decb42d9375ed7f2a37.pdfzataria multifloraessential oilhematological parametersbiochemical parametersclinical study |
| spellingShingle | Arash Jafari Mohammad Moazeni Seyed Vahid Hosseini Hajar Khazraei Samane Nematolahi Seyed Mohammad Kazem Tadayon Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease Iranian Journal of Colorectal Research zataria multiflora essential oil hematological parameters biochemical parameters clinical study |
| title | Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease |
| title_full | Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease |
| title_fullStr | Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease |
| title_full_unstemmed | Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease |
| title_short | Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease |
| title_sort | alteration in hematological and biochemical parameters following the long term consumption of zataria multiflora essential oil in patients infected with liver hydatid disease |
| topic | zataria multiflora essential oil hematological parameters biochemical parameters clinical study |
| url | https://colorectalresearch.sums.ac.ir/article_46473_6fedafc1d0ba4decb42d9375ed7f2a37.pdf |
| work_keys_str_mv | AT arashjafari alterationinhematologicalandbiochemicalparametersfollowingthelongtermconsumptionofzatariamultifloraessentialoilinpatientsinfectedwithliverhydatiddisease AT mohammadmoazeni alterationinhematologicalandbiochemicalparametersfollowingthelongtermconsumptionofzatariamultifloraessentialoilinpatientsinfectedwithliverhydatiddisease AT seyedvahidhosseini alterationinhematologicalandbiochemicalparametersfollowingthelongtermconsumptionofzatariamultifloraessentialoilinpatientsinfectedwithliverhydatiddisease AT hajarkhazraei alterationinhematologicalandbiochemicalparametersfollowingthelongtermconsumptionofzatariamultifloraessentialoilinpatientsinfectedwithliverhydatiddisease AT samanenematolahi alterationinhematologicalandbiochemicalparametersfollowingthelongtermconsumptionofzatariamultifloraessentialoilinpatientsinfectedwithliverhydatiddisease AT seyedmohammadkazemtadayon alterationinhematologicalandbiochemicalparametersfollowingthelongtermconsumptionofzatariamultifloraessentialoilinpatientsinfectedwithliverhydatiddisease |