Study of cytokine therapeutic effect of dyalderon in the scheme of treatment of cattle for disease caused by Pseudomonas aeruginosa
The article covers information on the study of cytokine therapeutic effect of dyalderon on some interleukin indices and other nonspecific immunity factors in Pseudomonas aeruginosa-infected cattle. The research was conducted on calves aged 2-2.5 months. They were divided into 3 groups 20 animals eac...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Federal Agricultural Research Center of the North-East named N.V. Rudnitsky
2018-08-01
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| Series: | Аграрная наука Евро-Северо-Востока |
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| Online Access: | https://www.agronauka-sv.ru/jour/article/view/243 |
| _version_ | 1826553945387958272 |
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| author | M. A. Azyamov T. V. Agalakova |
| author_facet | M. A. Azyamov T. V. Agalakova |
| author_sort | M. A. Azyamov |
| collection | DOAJ |
| description | The article covers information on the study of cytokine therapeutic effect of dyalderon on some interleukin indices and other nonspecific immunity factors in Pseudomonas aeruginosa-infected cattle. The research was conducted on calves aged 2-2.5 months. They were divided into 3 groups 20 animals each, according to analogue principle. The first group included clinically healthy animals. The calves of the 2-nd experimental group ill with pseudomonosis were treated using antibiotics and symptomatic medications according to the following scheme: in a day they were administered tobramycin sulfate in a dose of 0.5 mg/kg per day during a week, the next day they were given azithromycin (Azitronite) at a dose of 2.0 ml, intramuscularly, during a week, in addition, they were given trivitum at a dose of 2.0 ml intramuscularly, 450 ml of 5% glucose in normal saline intravenously. Pseudomonosis-infected calves of the 3-d experimental group in addition to antibiotic therapy were given dyalderon at a dose of 200 mg per 1 head intramuscularly, once a day during 7 days. On the fifth day animals of the 3 -d experimental group showed absence of laryngotracheitis and bronchitis symptoms as opposed to the 2-nd experimental group calves. On the 18-th day calves of the 3-d experimental group showed normalization of white blood cells, lymphocytes and red blood cells count, ESR (blood sedimentation rate) decreased from 27.8±0.04 to 9.2±0.52 mm/h (Р |
| first_indexed | 2024-03-07T19:20:24Z |
| format | Article |
| id | doaj.art-ca90aeb903904bdcac45aac8d326fe01 |
| institution | Directory Open Access Journal |
| issn | 2072-9081 2500-1396 |
| language | Russian |
| last_indexed | 2025-03-14T07:33:05Z |
| publishDate | 2018-08-01 |
| publisher | Federal Agricultural Research Center of the North-East named N.V. Rudnitsky |
| record_format | Article |
| series | Аграрная наука Евро-Северо-Востока |
| spelling | doaj.art-ca90aeb903904bdcac45aac8d326fe012025-03-03T09:39:13ZrusFederal Agricultural Research Center of the North-East named N.V. RudnitskyАграрная наука Евро-Северо-Востока2072-90812500-13962018-08-01654939710.30766/2072-9081.2018.65.4.93-97242Study of cytokine therapeutic effect of dyalderon in the scheme of treatment of cattle for disease caused by Pseudomonas aeruginosaM. A. Azyamov0T. V. Agalakova1Federal Agricultural Research Center of the North-East named N. V.RudnitskyFederal Agricultural Research Center of the North-East named N. V.RudnitskyThe article covers information on the study of cytokine therapeutic effect of dyalderon on some interleukin indices and other nonspecific immunity factors in Pseudomonas aeruginosa-infected cattle. The research was conducted on calves aged 2-2.5 months. They were divided into 3 groups 20 animals each, according to analogue principle. The first group included clinically healthy animals. The calves of the 2-nd experimental group ill with pseudomonosis were treated using antibiotics and symptomatic medications according to the following scheme: in a day they were administered tobramycin sulfate in a dose of 0.5 mg/kg per day during a week, the next day they were given azithromycin (Azitronite) at a dose of 2.0 ml, intramuscularly, during a week, in addition, they were given trivitum at a dose of 2.0 ml intramuscularly, 450 ml of 5% glucose in normal saline intravenously. Pseudomonosis-infected calves of the 3-d experimental group in addition to antibiotic therapy were given dyalderon at a dose of 200 mg per 1 head intramuscularly, once a day during 7 days. On the fifth day animals of the 3 -d experimental group showed absence of laryngotracheitis and bronchitis symptoms as opposed to the 2-nd experimental group calves. On the 18-th day calves of the 3-d experimental group showed normalization of white blood cells, lymphocytes and red blood cells count, ESR (blood sedimentation rate) decreased from 27.8±0.04 to 9.2±0.52 mm/h (Рhttps://www.agronauka-sv.ru/jour/article/view/243dyalderoninterleukinsleucocyteslipoxygenasemarkerspseudomonas aeruginosacalves |
| spellingShingle | M. A. Azyamov T. V. Agalakova Study of cytokine therapeutic effect of dyalderon in the scheme of treatment of cattle for disease caused by Pseudomonas aeruginosa Аграрная наука Евро-Северо-Востока dyalderon interleukins leucocytes lipoxygenase markers pseudomonas aeruginosa calves |
| title | Study of cytokine therapeutic effect of dyalderon in the scheme of treatment of cattle for disease caused by Pseudomonas aeruginosa |
| title_full | Study of cytokine therapeutic effect of dyalderon in the scheme of treatment of cattle for disease caused by Pseudomonas aeruginosa |
| title_fullStr | Study of cytokine therapeutic effect of dyalderon in the scheme of treatment of cattle for disease caused by Pseudomonas aeruginosa |
| title_full_unstemmed | Study of cytokine therapeutic effect of dyalderon in the scheme of treatment of cattle for disease caused by Pseudomonas aeruginosa |
| title_short | Study of cytokine therapeutic effect of dyalderon in the scheme of treatment of cattle for disease caused by Pseudomonas aeruginosa |
| title_sort | study of cytokine therapeutic effect of dyalderon in the scheme of treatment of cattle for disease caused by pseudomonas aeruginosa |
| topic | dyalderon interleukins leucocytes lipoxygenase markers pseudomonas aeruginosa calves |
| url | https://www.agronauka-sv.ru/jour/article/view/243 |
| work_keys_str_mv | AT maazyamov studyofcytokinetherapeuticeffectofdyalderonintheschemeoftreatmentofcattlefordiseasecausedbypseudomonasaeruginosa AT tvagalakova studyofcytokinetherapeuticeffectofdyalderonintheschemeoftreatmentofcattlefordiseasecausedbypseudomonasaeruginosa |