The Synergistic Influence of Polyflavonoids from <i>Citrus aurantifolia</i> on Diabetes Treatment and Their Modulation of the PI3K/AKT/FOXO1 Signaling Pathways: Molecular Docking Analyses and In Vivo Investigations

The Synergistic Influence of Polyflavonoids from <i>Citrus aurantifolia</i> on Diabetes Treatment and Their Modulation of the PI3K/AKT/FOXO1 Signaling Pathways: Molecular Docking Analyses and In Vivo Investigations

This study was aimed at probing the modulatory influence of polyflavonoids extracted from <i>Citrus aurantifolia</i>, lemon peel extract (LPE-polyflavonoids), on attenuating diabetes mellitus (DM) and its complications. HPLC investigations of the LPE exhibited the incidence of five flavo...

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Bibliographic Details
Main Authors: Mohamed A. Hassan, Ghada M. Abd Elmageed, Ibtehal G. El-Qazaz, Doaa S. El-Sayed, Lamia M. El-Samad, Heba M. Abdou
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceutics
Subjects:
diabetes mellitus
diosmin
FOXO1
hesperidin
high fructose/streptozotocin
lemon peel extract-polyflavonoids
Online Access:https://www.mdpi.com/1999-4923/15/9/2306

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