Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?
<p>Abstract</p> <p>Our inability to cure HIV/AIDS is related to the ability of the virus to establish reservoirs during treatment. In order to develop new strategies, it is certainly essential that a suitable animal model be implemented. In the recent work of Shytaj et al., it has...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-09-01
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| Series: | Retrovirology |
| Subjects: | |
| Online Access: | http://www.retrovirology.com/content/9/1/75 |
| _version_ | 1811249395767705600 |
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| author | Savarino Andrea Garaci Enrico |
| author_facet | Savarino Andrea Garaci Enrico |
| author_sort | Savarino Andrea |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Our inability to cure HIV/AIDS is related to the ability of the virus to establish reservoirs during treatment. In order to develop new strategies, it is certainly essential that a suitable animal model be implemented. In the recent work of Shytaj et al., it has been possible to inhibit viral replication to levels below the assay detection limit in the macaque AIDS model. Moreover, different therapeutic regimens applied to the rhesus macaque AIDS model (herein reviewed), including ours, are starting to show the potential to induce, following therapy suspension, conditions reminiscent of a drug-free control of the infection.</p> |
| first_indexed | 2024-04-12T15:45:48Z |
| format | Article |
| id | doaj.art-ca934afd619f44b180d6a74400a9ca62 |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-04-12T15:45:48Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-ca934afd619f44b180d6a74400a9ca622022-12-22T03:26:40ZengBMCRetrovirology1742-46902012-09-01917510.1186/1742-4690-9-75Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?Savarino AndreaGaraci Enrico<p>Abstract</p> <p>Our inability to cure HIV/AIDS is related to the ability of the virus to establish reservoirs during treatment. In order to develop new strategies, it is certainly essential that a suitable animal model be implemented. In the recent work of Shytaj et al., it has been possible to inhibit viral replication to levels below the assay detection limit in the macaque AIDS model. Moreover, different therapeutic regimens applied to the rhesus macaque AIDS model (herein reviewed), including ours, are starting to show the potential to induce, following therapy suspension, conditions reminiscent of a drug-free control of the infection.</p>http://www.retrovirology.com/content/9/1/75Macaque AIDS modelFunctional cureAntiretroviral therapyCentral memory CD4<sup>+</sup> T-cellsMaravirocAuranofinButhionine sulfoximine (BSO)Anti-reservoir |
| spellingShingle | Savarino Andrea Garaci Enrico Therapeutic imprinting of the immune system: towards a remission of AIDS in primates? Retrovirology Macaque AIDS model Functional cure Antiretroviral therapy Central memory CD4<sup>+</sup> T-cells Maraviroc Auranofin Buthionine sulfoximine (BSO) Anti-reservoir |
| title | Therapeutic imprinting of the immune system: towards a remission of AIDS in primates? |
| title_full | Therapeutic imprinting of the immune system: towards a remission of AIDS in primates? |
| title_fullStr | Therapeutic imprinting of the immune system: towards a remission of AIDS in primates? |
| title_full_unstemmed | Therapeutic imprinting of the immune system: towards a remission of AIDS in primates? |
| title_short | Therapeutic imprinting of the immune system: towards a remission of AIDS in primates? |
| title_sort | therapeutic imprinting of the immune system towards a remission of aids in primates |
| topic | Macaque AIDS model Functional cure Antiretroviral therapy Central memory CD4<sup>+</sup> T-cells Maraviroc Auranofin Buthionine sulfoximine (BSO) Anti-reservoir |
| url | http://www.retrovirology.com/content/9/1/75 |
| work_keys_str_mv | AT savarinoandrea therapeuticimprintingoftheimmunesystemtowardsaremissionofaidsinprimates AT garacienrico therapeuticimprintingoftheimmunesystemtowardsaremissionofaidsinprimates |