| Summary: | Abstract Background The search for novel pharmacotherapy from medicinal plants for central nervous system (CNS) disorders has become of importance since new agents with improved efficacy for more effective therapy are required. Sesamum indicum has been extensively used in Bangladesh and other Indian Subcontinent as medication for various diseases including CNS disorders. It was found to have antioxidant, antitumor, antihypertensive, neuroprotective, hypoglycemic, antimicrobial, anticonvulsant and wound healing activity. Results The result showed robust and dose-dependent antidepressant-like activity. There are statistically significant (p* < 0.05) reductions in the duration of immobility time both in forced swimming and tail suspension test. In open field test, measurement of locomotion, defecation and rearing are evaluated. There is statistically significant (p* < 0.05) increase in locomotion, rearing and defecation of mice compared to control group. Conclusions These results clearly demonstrates that methanolic extract of the seeds of Sesamum indicum has potential antidepressant activity and further studies should be conducted to identify, isolate and evaluate its potential active compound responsible for such effect.
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