Evaluation of the antidepressant-like activity of the methanolic extract of the seeds of Sesamum indicum
Abstract Background The search for novel pharmacotherapy from medicinal plants for central nervous system (CNS) disorders has become of importance since new agents with improved efficacy for more effective therapy are required. Sesamum indicum has been extensively used in Bangladesh and other Indian...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-01-01
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| Series: | Clinical Phytoscience |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40816-018-0098-3 |
| _version_ | 1818180486451691520 |
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| author | Md Rashidur Rahman Mostakim Sharif Mohammad Ali Sheikh Shahriar Rajib |
| author_facet | Md Rashidur Rahman Mostakim Sharif Mohammad Ali Sheikh Shahriar Rajib |
| author_sort | Md Rashidur Rahman |
| collection | DOAJ |
| description | Abstract Background The search for novel pharmacotherapy from medicinal plants for central nervous system (CNS) disorders has become of importance since new agents with improved efficacy for more effective therapy are required. Sesamum indicum has been extensively used in Bangladesh and other Indian Subcontinent as medication for various diseases including CNS disorders. It was found to have antioxidant, antitumor, antihypertensive, neuroprotective, hypoglycemic, antimicrobial, anticonvulsant and wound healing activity. Results The result showed robust and dose-dependent antidepressant-like activity. There are statistically significant (p* < 0.05) reductions in the duration of immobility time both in forced swimming and tail suspension test. In open field test, measurement of locomotion, defecation and rearing are evaluated. There is statistically significant (p* < 0.05) increase in locomotion, rearing and defecation of mice compared to control group. Conclusions These results clearly demonstrates that methanolic extract of the seeds of Sesamum indicum has potential antidepressant activity and further studies should be conducted to identify, isolate and evaluate its potential active compound responsible for such effect. |
| first_indexed | 2024-12-11T21:20:32Z |
| format | Article |
| id | doaj.art-ca945ac307f946e993d6dd44888a8a8d |
| institution | Directory Open Access Journal |
| issn | 2199-1197 |
| language | English |
| last_indexed | 2024-12-11T21:20:32Z |
| publishDate | 2019-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Clinical Phytoscience |
| spelling | doaj.art-ca945ac307f946e993d6dd44888a8a8d2022-12-22T00:50:29ZengSpringerOpenClinical Phytoscience2199-11972019-01-01511610.1186/s40816-018-0098-3Evaluation of the antidepressant-like activity of the methanolic extract of the seeds of Sesamum indicumMd Rashidur Rahman0Mostakim Sharif1Mohammad Ali2Sheikh Shahriar Rajib3Department of Pharmacy, Jessore University of Science & TechnologyDepartment of Pharmacy, Jessore University of Science & TechnologyDepartment of Pharmacy, Jessore University of Science & TechnologyDepartment of Pharmacy, Jessore University of Science & TechnologyAbstract Background The search for novel pharmacotherapy from medicinal plants for central nervous system (CNS) disorders has become of importance since new agents with improved efficacy for more effective therapy are required. Sesamum indicum has been extensively used in Bangladesh and other Indian Subcontinent as medication for various diseases including CNS disorders. It was found to have antioxidant, antitumor, antihypertensive, neuroprotective, hypoglycemic, antimicrobial, anticonvulsant and wound healing activity. Results The result showed robust and dose-dependent antidepressant-like activity. There are statistically significant (p* < 0.05) reductions in the duration of immobility time both in forced swimming and tail suspension test. In open field test, measurement of locomotion, defecation and rearing are evaluated. There is statistically significant (p* < 0.05) increase in locomotion, rearing and defecation of mice compared to control group. Conclusions These results clearly demonstrates that methanolic extract of the seeds of Sesamum indicum has potential antidepressant activity and further studies should be conducted to identify, isolate and evaluate its potential active compound responsible for such effect.http://link.springer.com/article/10.1186/s40816-018-0098-3AntidepressantDepressionSesameTSTFSTOFT |
| spellingShingle | Md Rashidur Rahman Mostakim Sharif Mohammad Ali Sheikh Shahriar Rajib Evaluation of the antidepressant-like activity of the methanolic extract of the seeds of Sesamum indicum Clinical Phytoscience Antidepressant Depression Sesame TST FST OFT |
| title | Evaluation of the antidepressant-like activity of the methanolic extract of the seeds of Sesamum indicum |
| title_full | Evaluation of the antidepressant-like activity of the methanolic extract of the seeds of Sesamum indicum |
| title_fullStr | Evaluation of the antidepressant-like activity of the methanolic extract of the seeds of Sesamum indicum |
| title_full_unstemmed | Evaluation of the antidepressant-like activity of the methanolic extract of the seeds of Sesamum indicum |
| title_short | Evaluation of the antidepressant-like activity of the methanolic extract of the seeds of Sesamum indicum |
| title_sort | evaluation of the antidepressant like activity of the methanolic extract of the seeds of sesamum indicum |
| topic | Antidepressant Depression Sesame TST FST OFT |
| url | http://link.springer.com/article/10.1186/s40816-018-0098-3 |
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