Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents
In this research, we report the size-controlled synthesis and surface-functionalization of magnetite with the natural antioxidant gallic acid (GA) as a ligand, using in situ and post-synthesis methods. GA functionalization provided narrow size distribution, with an average particle size of 5 and 8 n...
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MDPI AG
2017-10-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/7/10/306 |
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| author | Syed Tawab Shah Wageeh A Yehya Omer Saad Khanom Simarani Zaira Chowdhury Abeer A. Alhadi Lina A. Al-Ani |
| author_facet | Syed Tawab Shah Wageeh A Yehya Omer Saad Khanom Simarani Zaira Chowdhury Abeer A. Alhadi Lina A. Al-Ani |
| author_sort | Syed Tawab Shah |
| collection | DOAJ |
| description | In this research, we report the size-controlled synthesis and surface-functionalization of magnetite with the natural antioxidant gallic acid (GA) as a ligand, using in situ and post-synthesis methods. GA functionalization provided narrow size distribution, with an average particle size of 5 and 8 nm for in situ synthesis of gallic acid functionalized magnetite IONP@GA1 and IONP@GA2, respectively, which are ultra-small particles as compared to unfunctionalized magnetite (IONP) and post functionalized magnetite IONP@GA3 with average size of 10 and 11 nm respectively. All the IONPs@GA samples were found hydrophilic with stable aggregation state. Prior to commencement of experimental lab work, PASS software was used to predict the biological activities of GA and it is found that experimental antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and antimicrobial studies using well diffusion method are in good agreement with the simulated results. Furthermore, the half maximal inhibitory concentration (IC50) values of DPPH antioxidant assay revealed a 2–4 fold decrease as compared to unfunctionalized IONP. In addition to antioxidant activity, all the three IONP@GA proved outstanding antimicrobial activity while testing on different bacterial and fungal strains. The results collectively indicate the successful fabrication of novel antioxidant, antimicrobial IONP@GA composite, which are magnetically separable, efficient, and low cost, with potential applications in polymers, cosmetics, and biomedical and food industries. |
| first_indexed | 2024-04-11T23:17:01Z |
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| id | doaj.art-ca94c14f82ed41539c619267493a75e4 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-04-11T23:17:01Z |
| publishDate | 2017-10-01 |
| publisher | MDPI AG |
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| series | Nanomaterials |
| spelling | doaj.art-ca94c14f82ed41539c619267493a75e42022-12-22T03:57:36ZengMDPI AGNanomaterials2079-49912017-10-0171030610.3390/nano7100306nano7100306Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial AgentsSyed Tawab Shah0Wageeh A Yehya1Omer Saad2Khanom Simarani3Zaira Chowdhury4Abeer A. Alhadi5Lina A. Al-Ani6Nanotechnology & Catalysis Research Centre (NANOCAT), University of Malaya, Block A, Level 3, Institute of Postgraduate Studies Building, Kuala Lumpur 50603, MalaysiaNanotechnology & Catalysis Research Centre (NANOCAT), University of Malaya, Block A, Level 3, Institute of Postgraduate Studies Building, Kuala Lumpur 50603, MalaysiaDepartment of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaInstitute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, MalaysiaNanotechnology & Catalysis Research Centre (NANOCAT), University of Malaya, Block A, Level 3, Institute of Postgraduate Studies Building, Kuala Lumpur 50603, MalaysiaDepartment of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaNanotechnology & Catalysis Research Centre (NANOCAT), University of Malaya, Block A, Level 3, Institute of Postgraduate Studies Building, Kuala Lumpur 50603, MalaysiaIn this research, we report the size-controlled synthesis and surface-functionalization of magnetite with the natural antioxidant gallic acid (GA) as a ligand, using in situ and post-synthesis methods. GA functionalization provided narrow size distribution, with an average particle size of 5 and 8 nm for in situ synthesis of gallic acid functionalized magnetite IONP@GA1 and IONP@GA2, respectively, which are ultra-small particles as compared to unfunctionalized magnetite (IONP) and post functionalized magnetite IONP@GA3 with average size of 10 and 11 nm respectively. All the IONPs@GA samples were found hydrophilic with stable aggregation state. Prior to commencement of experimental lab work, PASS software was used to predict the biological activities of GA and it is found that experimental antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and antimicrobial studies using well diffusion method are in good agreement with the simulated results. Furthermore, the half maximal inhibitory concentration (IC50) values of DPPH antioxidant assay revealed a 2–4 fold decrease as compared to unfunctionalized IONP. In addition to antioxidant activity, all the three IONP@GA proved outstanding antimicrobial activity while testing on different bacterial and fungal strains. The results collectively indicate the successful fabrication of novel antioxidant, antimicrobial IONP@GA composite, which are magnetically separable, efficient, and low cost, with potential applications in polymers, cosmetics, and biomedical and food industries.https://www.mdpi.com/2079-4991/7/10/306gallic acidnanoantioxidantDPPHfunctionalizationantimicrobial |
| spellingShingle | Syed Tawab Shah Wageeh A Yehya Omer Saad Khanom Simarani Zaira Chowdhury Abeer A. Alhadi Lina A. Al-Ani Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents Nanomaterials gallic acid nanoantioxidant DPPH functionalization antimicrobial |
| title | Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents |
| title_full | Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents |
| title_fullStr | Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents |
| title_full_unstemmed | Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents |
| title_short | Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents |
| title_sort | surface functionalization of iron oxide nanoparticles with gallic acid as potential antioxidant and antimicrobial agents |
| topic | gallic acid nanoantioxidant DPPH functionalization antimicrobial |
| url | https://www.mdpi.com/2079-4991/7/10/306 |
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