Determinants of quality of life in Nigerian female patients with epilepsy on carbamazepine and levetiracetam monotherapy
Abstract Background The study is aimed to identify the predictors of Quality of Life (QOL) in women with epilepsy (WWE) on carbamazepine (CBM) and levetiracetam (LTM) monotherapy. 100 WWE were recruited (50 each on CBM and LTM), after clinical diagnosis of epilepsy supported by Electroencephalograph...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-03-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-023-00631-9 |
| _version_ | 1797865269787361280 |
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| author | Ogunjimi Luqman Yaria Joseph Makanjuola Akintomiwa Alabi Akinyinka Aderinola Aderonke Osalusi Bamidele Oboh David Olusola-Bello Mojisola Falujo Bolanle Murtala Abdullahi Olawale Olatunbosun Fatai Fehintola Ogunniyi Adesola |
| author_facet | Ogunjimi Luqman Yaria Joseph Makanjuola Akintomiwa Alabi Akinyinka Aderinola Aderonke Osalusi Bamidele Oboh David Olusola-Bello Mojisola Falujo Bolanle Murtala Abdullahi Olawale Olatunbosun Fatai Fehintola Ogunniyi Adesola |
| author_sort | Ogunjimi Luqman |
| collection | DOAJ |
| description | Abstract Background The study is aimed to identify the predictors of Quality of Life (QOL) in women with epilepsy (WWE) on carbamazepine (CBM) and levetiracetam (LTM) monotherapy. 100 WWE were recruited (50 each on CBM and LTM), after clinical diagnosis of epilepsy supported by Electroencephalography (EEG) features and seizures classification by 2017 International League Against Epilepsy (ILAE) criteria, the Quality of Life Inventory Scale 31(QOLIE-31) and Zung Self-Rating Depression Scale (ZSRDS) were used to assess QOL and depression, respectively. Result Higher QOLIE-31 scores was seen in the LTM group across all domains except seizure worry (p = 0.051) compared to CBM group. Logistic regression showed that the use of CBM (p = 0.000), fast frequency on EEG (p = 0.005), longer duration of epilepsy (p = 0.017), presence of depression (p = 0.008) and lower level of education (p = 0.003) were predictors of QOL. Progesterone (p = 0.040), oestradiol (p = 0.011) and prolactin (p = 0.002) in follicular phase showed significant association with QOLIE-total score. In the luteal phase, luteinizing hormone–follicle stimulating hormone (LH–FSH) ratio (p = 0.009) and testosterone (p = 0.015), FSH (p = 0.015), prolactin (p = 0.000), showed significant association with QOL. None of the hormones independently predicts QOL. Conclusion LTM group appears to have better QOL than CBM group. Healthcare providers should focus on addressing these identified predictors which include medication effect, depression, Level of education, EEG background and duration of epilepsy with aim of improving QOL. |
| first_indexed | 2024-04-09T23:05:39Z |
| format | Article |
| id | doaj.art-ca9514dc01084298b331fdcaf31e295c |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-04-09T23:05:39Z |
| publishDate | 2023-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-ca9514dc01084298b331fdcaf31e295c2023-03-22T10:43:49ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292023-03-0159111110.1186/s41983-023-00631-9Determinants of quality of life in Nigerian female patients with epilepsy on carbamazepine and levetiracetam monotherapyOgunjimi Luqman0Yaria Joseph1Makanjuola Akintomiwa2Alabi Akinyinka3Aderinola Aderonke4Osalusi Bamidele5Oboh David6Olusola-Bello Mojisola7Falujo Bolanle8Murtala Abdullahi9Olawale Olatunbosun10Fatai Fehintola11Ogunniyi Adesola12Department of Pharmacology and Therapeutics, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo UniversityDivision of Neurology, Department of Medicine, University College HospitalDivision of Neurology, Department of Medicine, University College HospitalDepartment of Pharmacology and Therapeutics, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo UniversityDepartment of Pharmacology and Therapeutics, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo UniversityDivision of Neurology, Department of Medicine, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo UniversityDepartment of Radiology, University College HospitalRadiology Department, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Ogun StateDepartment of Pharmacology and Therapeutics, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo UniversityDepartment of Pharmacology and Therapeutics, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo UniversityDepartment of Chemical Pathology and Immunology, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Ogun StateDepartment of Pharmacology and Therapeutics, University College HospitalDivision of Neurology, Department of Medicine, University College HospitalAbstract Background The study is aimed to identify the predictors of Quality of Life (QOL) in women with epilepsy (WWE) on carbamazepine (CBM) and levetiracetam (LTM) monotherapy. 100 WWE were recruited (50 each on CBM and LTM), after clinical diagnosis of epilepsy supported by Electroencephalography (EEG) features and seizures classification by 2017 International League Against Epilepsy (ILAE) criteria, the Quality of Life Inventory Scale 31(QOLIE-31) and Zung Self-Rating Depression Scale (ZSRDS) were used to assess QOL and depression, respectively. Result Higher QOLIE-31 scores was seen in the LTM group across all domains except seizure worry (p = 0.051) compared to CBM group. Logistic regression showed that the use of CBM (p = 0.000), fast frequency on EEG (p = 0.005), longer duration of epilepsy (p = 0.017), presence of depression (p = 0.008) and lower level of education (p = 0.003) were predictors of QOL. Progesterone (p = 0.040), oestradiol (p = 0.011) and prolactin (p = 0.002) in follicular phase showed significant association with QOLIE-total score. In the luteal phase, luteinizing hormone–follicle stimulating hormone (LH–FSH) ratio (p = 0.009) and testosterone (p = 0.015), FSH (p = 0.015), prolactin (p = 0.000), showed significant association with QOL. None of the hormones independently predicts QOL. Conclusion LTM group appears to have better QOL than CBM group. Healthcare providers should focus on addressing these identified predictors which include medication effect, depression, Level of education, EEG background and duration of epilepsy with aim of improving QOL.https://doi.org/10.1186/s41983-023-00631-9Quality of lifeEpilepsyHormoneAnti-epileptic drug |
| spellingShingle | Ogunjimi Luqman Yaria Joseph Makanjuola Akintomiwa Alabi Akinyinka Aderinola Aderonke Osalusi Bamidele Oboh David Olusola-Bello Mojisola Falujo Bolanle Murtala Abdullahi Olawale Olatunbosun Fatai Fehintola Ogunniyi Adesola Determinants of quality of life in Nigerian female patients with epilepsy on carbamazepine and levetiracetam monotherapy The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Quality of life Epilepsy Hormone Anti-epileptic drug |
| title | Determinants of quality of life in Nigerian female patients with epilepsy on carbamazepine and levetiracetam monotherapy |
| title_full | Determinants of quality of life in Nigerian female patients with epilepsy on carbamazepine and levetiracetam monotherapy |
| title_fullStr | Determinants of quality of life in Nigerian female patients with epilepsy on carbamazepine and levetiracetam monotherapy |
| title_full_unstemmed | Determinants of quality of life in Nigerian female patients with epilepsy on carbamazepine and levetiracetam monotherapy |
| title_short | Determinants of quality of life in Nigerian female patients with epilepsy on carbamazepine and levetiracetam monotherapy |
| title_sort | determinants of quality of life in nigerian female patients with epilepsy on carbamazepine and levetiracetam monotherapy |
| topic | Quality of life Epilepsy Hormone Anti-epileptic drug |
| url | https://doi.org/10.1186/s41983-023-00631-9 |
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