Effect of nicotinic acid on the survival rate, and neurodegeneration of transgenic Drosophila melanogasterwith overexpression of human APP gene

Effect of nicotinic acid on the survival rate, and neurodegeneration of transgenic Drosophila melanogasterwith overexpression of human APP gene

Transgenic Drosophila melanogaster lines modeling the main neuromorphological markers of Alzheimer's disease were used to study the neuroprotective properties of nicotinic acid. Thirty days old flies treated with nicotinic acid showed better survival rate and reduced neurodegeneration.

Bibliographic Details
Main Authors: O. I. Bolshakova, D. I. Rodin, S. I. Timoshenko, E. M. Latypova, S. V. Sarantseva
Format: Article
Language:Russian
Published: Academician I.P. Pavlov First St. Petersburg State Medical University 2013-09-01
Series:Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Subjects:
nicotinic acid
alzheimer''s disease
drosophila melanogaster
Online Access:https://www.sci-notes.ru/jour/article/view/218

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