Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relatives
Recent studies suggested that the rich club organization promoting global brain communication and integration of information, may be abnormally increased in obsessive-compulsive disorder (OCD). However, the structural and functional basis of this organization is still not very clear. Given the herit...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158221002527 |
| _version_ | 1818572827635220480 |
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| author | Ziwen Peng Xinyi Yang Chuanyong Xu Xiangshu Wu Qiong Yang Zhen Wei Zihan Zhou Tom Verguts Qi Chen |
| author_facet | Ziwen Peng Xinyi Yang Chuanyong Xu Xiangshu Wu Qiong Yang Zhen Wei Zihan Zhou Tom Verguts Qi Chen |
| author_sort | Ziwen Peng |
| collection | DOAJ |
| description | Recent studies suggested that the rich club organization promoting global brain communication and integration of information, may be abnormally increased in obsessive-compulsive disorder (OCD). However, the structural and functional basis of this organization is still not very clear. Given the heritability of OCD, as suggested by previous family-based studies, we hypothesize that aberrant rich club organization may be a trait marker for OCD. In the present study, 32 patients with OCD, 30 unaffected first-degree relatives (FDR) and 32 healthy controls (HC) underwent diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI). We examined the structural rich club organization and its interrelationship with functional coupling. Our results showed that rich club and peripheral connection strength in patients with OCD was lower than in HC, while it was intermediate in FDR. Finally, the coupling between structural and functional connections of the rich club, was decreased in FDR but not in OCD relative to HC, which suggests a buffering mechanism of brain functions in FDR. Overall, our findings suggest that alteration of the rich club organization may reflect a vulnerability biomarker for OCD, possibly buffered by structural and functional coupling of the rich club. |
| first_indexed | 2024-12-15T00:02:51Z |
| format | Article |
| id | doaj.art-ca9c9212e846435c84484e384a0e6400 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-15T00:02:51Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-ca9c9212e846435c84484e384a0e64002022-12-21T22:42:51ZengElsevierNeuroImage: Clinical2213-15822021-01-0132102808Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relativesZiwen Peng0Xinyi Yang1Chuanyong Xu2Xiangshu Wu3Qiong Yang4Zhen Wei5Zihan Zhou6Tom Verguts7Qi Chen8Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education China, School of Psychology, Center for Studies of Psychological Application, And Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, China; Corresponding authors at: School of Psychology, South China Normal University, No. 55, West of Zhongshan Avenue, Guangzhou 510631, China.Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education China, School of Psychology, Center for Studies of Psychological Application, And Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, ChinaKey Laboratory of Brain, Cognition and Education Sciences, Ministry of Education China, School of Psychology, Center for Studies of Psychological Application, And Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, ChinaKey Laboratory of Brain, Cognition and Education Sciences, Ministry of Education China, School of Psychology, Center for Studies of Psychological Application, And Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, ChinaSouthern Medical University, Guangzhou, China; Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, ChinaDepartment of Child Psychiatry and Rehabilitation, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, ChinaKey Laboratory of Brain, Cognition and Education Sciences, Ministry of Education China, School of Psychology, Center for Studies of Psychological Application, And Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, ChinaDepartment of Experimental Psychology, Ghent University, Ghent, BelgiumKey Laboratory of Brain, Cognition and Education Sciences, Ministry of Education China, School of Psychology, Center for Studies of Psychological Application, And Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, China; Corresponding authors at: School of Psychology, South China Normal University, No. 55, West of Zhongshan Avenue, Guangzhou 510631, China.Recent studies suggested that the rich club organization promoting global brain communication and integration of information, may be abnormally increased in obsessive-compulsive disorder (OCD). However, the structural and functional basis of this organization is still not very clear. Given the heritability of OCD, as suggested by previous family-based studies, we hypothesize that aberrant rich club organization may be a trait marker for OCD. In the present study, 32 patients with OCD, 30 unaffected first-degree relatives (FDR) and 32 healthy controls (HC) underwent diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI). We examined the structural rich club organization and its interrelationship with functional coupling. Our results showed that rich club and peripheral connection strength in patients with OCD was lower than in HC, while it was intermediate in FDR. Finally, the coupling between structural and functional connections of the rich club, was decreased in FDR but not in OCD relative to HC, which suggests a buffering mechanism of brain functions in FDR. Overall, our findings suggest that alteration of the rich club organization may reflect a vulnerability biomarker for OCD, possibly buffered by structural and functional coupling of the rich club.http://www.sciencedirect.com/science/article/pii/S2213158221002527Obsessive-compulsive disorderVulnerabilityRich club organizationPeripheral connectionsDiffusion tensor imaging |
| spellingShingle | Ziwen Peng Xinyi Yang Chuanyong Xu Xiangshu Wu Qiong Yang Zhen Wei Zihan Zhou Tom Verguts Qi Chen Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relatives NeuroImage: Clinical Obsessive-compulsive disorder Vulnerability Rich club organization Peripheral connections Diffusion tensor imaging |
| title | Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relatives |
| title_full | Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relatives |
| title_fullStr | Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relatives |
| title_full_unstemmed | Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relatives |
| title_short | Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relatives |
| title_sort | aberrant rich club organization in patients with obsessive compulsive disorder and their unaffected first degree relatives |
| topic | Obsessive-compulsive disorder Vulnerability Rich club organization Peripheral connections Diffusion tensor imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2213158221002527 |
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