Endogenous formaldehyde turnover in humans compared with exogenous contribution from food sources
The FEEDAP Panel received a request to deliver a scientific opinion on the safety and efficacy of formaldehyde used in feed for all animal species based on dossiers submitted by applicants. In parallel, the ANS Panel evaluated the safety of formaldehyde formed from endogenous production and from die...
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| Format: | Article |
| Language: | English |
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Wiley
2014-02-01
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| Series: | EFSA Journal |
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| Online Access: | http://www.efsa.europa.eu/en/efsajournal/doc/3550.pdf |
| _version_ | 1818406260447379456 |
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| author | European Food Safety Authority |
| author_facet | European Food Safety Authority |
| author_sort | European Food Safety Authority |
| collection | DOAJ |
| description | The FEEDAP Panel received a request to deliver a scientific opinion on the safety and efficacy of formaldehyde used in feed for all animal species based on dossiers submitted by applicants. In parallel, the ANS Panel evaluated the safety of formaldehyde formed from endogenous production and from dietary sources of methanol, including aspartame. In order to support both evaluations, assistance was requested to the SCER unit to evaluate the oral internal dose of formaldehyde in humans from endogenous production, food-derived from target animals exposed to formaldehyde-treated feed and formaldehyde generated from dietary sources of methanol, including from food additives such as aspartame. Endogenous turnover of formaldehyde was estimated to be approximately 0.61-0.91 mg/kg bw per minute and 878-1310 mg/kg bw per day assuming a half life of 1 1.5 min. Compared with formaldehyde turnover and the background levels of formaldehyde from food sources (1.7-1.4 mg/kg b. w per day for a 60-70 kg person), including from dietary methanol, the relative contribution of exogenous formaldehyde from consumption of animal products (milk, meat) from target animals exposed to formaldehyde-treated feed was negligible (<0.001 %). Oral exposure to formaldehyde from aspartame involves metabolism to methanol and further oxidation to formaldehyde. At the current ADI of 40 mg/kg bw per day for aspartame, formaldehyde would be approximately 4 mg/kg bw per day and represent only 0.3-0.4 % of the endogenous turnover of formaldehyde. |
| first_indexed | 2024-12-14T09:09:07Z |
| format | Article |
| id | doaj.art-ca9d6e76b08843c5a43694ee363bdf5c |
| institution | Directory Open Access Journal |
| issn | 1831-4732 |
| language | English |
| last_indexed | 2024-12-14T09:09:07Z |
| publishDate | 2014-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj.art-ca9d6e76b08843c5a43694ee363bdf5c2022-12-21T23:08:37ZengWileyEFSA Journal1831-47322014-02-0112210.2903/j.efsa.2014.3550EFSA Journal 2014;12(2):3550Endogenous formaldehyde turnover in humans compared with exogenous contribution from food sourcesEuropean Food Safety AuthorityThe FEEDAP Panel received a request to deliver a scientific opinion on the safety and efficacy of formaldehyde used in feed for all animal species based on dossiers submitted by applicants. In parallel, the ANS Panel evaluated the safety of formaldehyde formed from endogenous production and from dietary sources of methanol, including aspartame. In order to support both evaluations, assistance was requested to the SCER unit to evaluate the oral internal dose of formaldehyde in humans from endogenous production, food-derived from target animals exposed to formaldehyde-treated feed and formaldehyde generated from dietary sources of methanol, including from food additives such as aspartame. Endogenous turnover of formaldehyde was estimated to be approximately 0.61-0.91 mg/kg bw per minute and 878-1310 mg/kg bw per day assuming a half life of 1 1.5 min. Compared with formaldehyde turnover and the background levels of formaldehyde from food sources (1.7-1.4 mg/kg b. w per day for a 60-70 kg person), including from dietary methanol, the relative contribution of exogenous formaldehyde from consumption of animal products (milk, meat) from target animals exposed to formaldehyde-treated feed was negligible (<0.001 %). Oral exposure to formaldehyde from aspartame involves metabolism to methanol and further oxidation to formaldehyde. At the current ADI of 40 mg/kg bw per day for aspartame, formaldehyde would be approximately 4 mg/kg bw per day and represent only 0.3-0.4 % of the endogenous turnover of formaldehyde.http://www.efsa.europa.eu/en/efsajournal/doc/3550.pdfformaldehydeendogenousbackground levelscarry-overaspartamemethanol |
| spellingShingle | European Food Safety Authority Endogenous formaldehyde turnover in humans compared with exogenous contribution from food sources EFSA Journal formaldehyde endogenous background levels carry-over aspartame methanol |
| title | Endogenous formaldehyde turnover in humans compared with exogenous contribution from food sources |
| title_full | Endogenous formaldehyde turnover in humans compared with exogenous contribution from food sources |
| title_fullStr | Endogenous formaldehyde turnover in humans compared with exogenous contribution from food sources |
| title_full_unstemmed | Endogenous formaldehyde turnover in humans compared with exogenous contribution from food sources |
| title_short | Endogenous formaldehyde turnover in humans compared with exogenous contribution from food sources |
| title_sort | endogenous formaldehyde turnover in humans compared with exogenous contribution from food sources |
| topic | formaldehyde endogenous background levels carry-over aspartame methanol |
| url | http://www.efsa.europa.eu/en/efsajournal/doc/3550.pdf |
| work_keys_str_mv | AT europeanfoodsafetyauthority endogenousformaldehydeturnoverinhumanscomparedwithexogenouscontributionfromfoodsources |