Experimental rugged fitness landscape in protein sequence space.
The fitness landscape in sequence space determines the process of biomolecular evolution. To plot the fitness landscape of protein function, we carried out in vitro molecular evolution beginning with a defective fd phage carrying a random polypeptide of 139 amino acids in place of the g3p minor coat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC1762315?pdf=render |