Low-Molecular Weight Polyethylenimine Modified with Pluronic 123 and RGD- or Chimeric RGD-NLS Peptide: Characteristics and Transfection Efficacy of Their Complexes with Plasmid DNA

Low-Molecular Weight Polyethylenimine Modified with Pluronic 123 and RGD- or Chimeric RGD-NLS Peptide: Characteristics and Transfection Efficacy of Their Complexes with Plasmid DNA

To solve the problem of transfection efficiency vs. cytotoxicity and tumor-targeting ability when polyethylenimine (PEI) was used as a nonviral gene delivery vector, new degradable PEI polymers were synthesized via cross-linking low-molecular-weight PEI with Pluronic P123 and then further coupled wi...

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Bibliographic Details
Main Authors: Jing Hu, Wenfang Zhao, Kehai Liu, Qian Yu, Yuan Mao, Zeyu Lu, Yaguang Zhang, Manman Zhu
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Molecules
Subjects:
polycations
RGD
nuclear localization signal
physico-chemical properties
transfection efficiency
Online Access:http://www.mdpi.com/1420-3049/21/5/655

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