New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies
Two new cationic Cu(II) complexes of cyclam (1,4,8,11-tetraazacyclotetradecane) and aminocarboxylate coligands glycine or alanine have been synthesized. The complexes were characterized by elemental analysis (C, H and N), molar electrical conductivity, magnetic susceptibility measurement at room tem...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2022-01-01
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| Series: | Journal of the Serbian Chemical Society |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2022/0352-51392200026D.pdf |
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| author | Dražić Branka Antonijević-Nikolić Mirjana Marinović-Cincović Milena Živković-Radovanović Vukosava Borović Branka Tanasković Slađana B. |
| author_facet | Dražić Branka Antonijević-Nikolić Mirjana Marinović-Cincović Milena Živković-Radovanović Vukosava Borović Branka Tanasković Slađana B. |
| author_sort | Dražić Branka |
| collection | DOAJ |
| description | Two new cationic Cu(II) complexes of cyclam (1,4,8,11-tetraazacyclotetradecane) and aminocarboxylate coligands glycine or alanine have been synthesized. The complexes were characterized by elemental analysis (C, H and N), molar electrical conductivity, magnetic susceptibility measurement at room temperature, spectral methods (UV/Vis and Fourier transform infrared), as well as by thermogravimetric (TG) and differential thermal analysis (DTA). The analytical data of the complexes show the formation of mononuclear complexes with general formula [Cu(L)cyc](ClO4)2·nH2O, A) L = glycine, n = 1.5 and B) L = alanine, n = 2.5. The tetradentate ligand cyclam was coordinated to metals through four N donors. The spectroscopic data suggested that the amino carboxylate ligands coordinated via their carboxylate ion moieties. The six- -coordinate octahedral geometry around Cu(II) in both complexes was presumed. TG-DTA analysis indicated that complex B decomposed exothermally in a single step in the range of 310–400°C. The cytotoxic activity of Cu(II) complexes and the starting ligands were tested against human cervix adenocarcinoma cell line (HeLa), human melanoma (FemX) and human colon carcinoma (LS174). The IC50 values for the Cu(II) complexes were from 48.35–82.25 μM. Both complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans. |
| first_indexed | 2024-12-11T16:24:33Z |
| format | Article |
| id | doaj.art-ca9f82ffec864ccba0d966c0b3276cf8 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-11T16:24:33Z |
| publishDate | 2022-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-ca9f82ffec864ccba0d966c0b3276cf82022-12-22T00:58:45ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212022-01-0187445146410.2298/JSC211107026D0352-51392200026DNew copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studiesDražić Branka0https://orcid.org/0000-0003-1723-3268Antonijević-Nikolić Mirjana1https://orcid.org/0000-0003-4277-9780Marinović-Cincović Milena2https://orcid.org/0000-0001-6197-1511Živković-Radovanović Vukosava3https://orcid.org/0000-0003-2558-4957Borović Branka4https://orcid.org/0000-0003-0371-0991Tanasković Slađana B.5https://orcid.org/0000-0002-3486-2800Faculty of Pharmacy, Belgrade, SerbiaAcademy of Applied Studies Šabac, Department for Medical, Business and Technological Studies, Šabac, SerbiaInstitute of Nuclear Sciences Vinča, University of Belgrade, Vinča, Belgrade, SerbiaFaculty of Chemistry, University of Belgrade, Belgrade, SerbiaInstitute of Meat Hygiene and Technology, Belgrade, SerbiaFaculty of Pharmacy, Belgrade, SerbiaTwo new cationic Cu(II) complexes of cyclam (1,4,8,11-tetraazacyclotetradecane) and aminocarboxylate coligands glycine or alanine have been synthesized. The complexes were characterized by elemental analysis (C, H and N), molar electrical conductivity, magnetic susceptibility measurement at room temperature, spectral methods (UV/Vis and Fourier transform infrared), as well as by thermogravimetric (TG) and differential thermal analysis (DTA). The analytical data of the complexes show the formation of mononuclear complexes with general formula [Cu(L)cyc](ClO4)2·nH2O, A) L = glycine, n = 1.5 and B) L = alanine, n = 2.5. The tetradentate ligand cyclam was coordinated to metals through four N donors. The spectroscopic data suggested that the amino carboxylate ligands coordinated via their carboxylate ion moieties. The six- -coordinate octahedral geometry around Cu(II) in both complexes was presumed. TG-DTA analysis indicated that complex B decomposed exothermally in a single step in the range of 310–400°C. The cytotoxic activity of Cu(II) complexes and the starting ligands were tested against human cervix adenocarcinoma cell line (HeLa), human melanoma (FemX) and human colon carcinoma (LS174). The IC50 values for the Cu(II) complexes were from 48.35–82.25 μM. Both complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans.http://www.doiserbia.nb.rs/img/doi/0352-5139/2022/0352-51392200026D.pdfcopper(ii) complexescyclamglycinealanineantimicrobial and cytotoxic activity |
| spellingShingle | Dražić Branka Antonijević-Nikolić Mirjana Marinović-Cincović Milena Živković-Radovanović Vukosava Borović Branka Tanasković Slađana B. New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies Journal of the Serbian Chemical Society copper(ii) complexes cyclam glycine alanine antimicrobial and cytotoxic activity |
| title | New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies |
| title_full | New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies |
| title_fullStr | New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies |
| title_full_unstemmed | New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies |
| title_short | New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies |
| title_sort | new copper ii cyclam complexes with aminocarboxylate co ligands synthesis characterization and in vitro antiproliferative and antibacterial studies |
| topic | copper(ii) complexes cyclam glycine alanine antimicrobial and cytotoxic activity |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2022/0352-51392200026D.pdf |
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