The Function of KDEL Receptors as UPR Genes in Disease
The KDEL receptor retrieval pathway is essential for maintaining resident proteins in the endoplasmic reticulum (ER) lumen. ER resident proteins serve a variety of functions, including protein folding and maturation. Perturbations to the lumenal ER microenvironment, such as calcium depletion, can ca...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/5436 |
| _version_ | 1797533232990781440 |
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| author | Emily S. Wires Kathleen A. Trychta Lacey M. Kennedy Brandon K. Harvey |
| author_facet | Emily S. Wires Kathleen A. Trychta Lacey M. Kennedy Brandon K. Harvey |
| author_sort | Emily S. Wires |
| collection | DOAJ |
| description | The KDEL receptor retrieval pathway is essential for maintaining resident proteins in the endoplasmic reticulum (ER) lumen. ER resident proteins serve a variety of functions, including protein folding and maturation. Perturbations to the lumenal ER microenvironment, such as calcium depletion, can cause protein misfolding and activation of the unfolded protein response (UPR). Additionally, ER resident proteins are secreted from the cell by overwhelming the KDEL receptor retrieval pathway. Recent data show that KDEL receptors are also activated during the UPR through the IRE1/XBP1 signaling pathway as an adaptive response to cellular stress set forth to reduce the loss of ER resident proteins. This review will discuss the emerging connection between UPR activation and KDEL receptors as it pertains to ER proteostasis and disease states. |
| first_indexed | 2024-03-10T11:11:38Z |
| format | Article |
| id | doaj.art-caa042c16c9e4db3b6d5dcfbe2929a1c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:11:38Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-caa042c16c9e4db3b6d5dcfbe2929a1c2023-11-21T20:45:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012211543610.3390/ijms22115436The Function of KDEL Receptors as UPR Genes in DiseaseEmily S. Wires0Kathleen A. Trychta1Lacey M. Kennedy2Brandon K. Harvey3Molecular Mechanisms of Cellular Stress and Inflammation, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USAMolecular Mechanisms of Cellular Stress and Inflammation, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USAMolecular Mechanisms of Cellular Stress and Inflammation, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USAMolecular Mechanisms of Cellular Stress and Inflammation, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USAThe KDEL receptor retrieval pathway is essential for maintaining resident proteins in the endoplasmic reticulum (ER) lumen. ER resident proteins serve a variety of functions, including protein folding and maturation. Perturbations to the lumenal ER microenvironment, such as calcium depletion, can cause protein misfolding and activation of the unfolded protein response (UPR). Additionally, ER resident proteins are secreted from the cell by overwhelming the KDEL receptor retrieval pathway. Recent data show that KDEL receptors are also activated during the UPR through the IRE1/XBP1 signaling pathway as an adaptive response to cellular stress set forth to reduce the loss of ER resident proteins. This review will discuss the emerging connection between UPR activation and KDEL receptors as it pertains to ER proteostasis and disease states.https://www.mdpi.com/1422-0067/22/11/5436KDEL receptorendoplasmic reticulumunfolded protein responseER resident proteinsdiseaseexodosis |
| spellingShingle | Emily S. Wires Kathleen A. Trychta Lacey M. Kennedy Brandon K. Harvey The Function of KDEL Receptors as UPR Genes in Disease International Journal of Molecular Sciences KDEL receptor endoplasmic reticulum unfolded protein response ER resident proteins disease exodosis |
| title | The Function of KDEL Receptors as UPR Genes in Disease |
| title_full | The Function of KDEL Receptors as UPR Genes in Disease |
| title_fullStr | The Function of KDEL Receptors as UPR Genes in Disease |
| title_full_unstemmed | The Function of KDEL Receptors as UPR Genes in Disease |
| title_short | The Function of KDEL Receptors as UPR Genes in Disease |
| title_sort | function of kdel receptors as upr genes in disease |
| topic | KDEL receptor endoplasmic reticulum unfolded protein response ER resident proteins disease exodosis |
| url | https://www.mdpi.com/1422-0067/22/11/5436 |
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