PDE4 Inhibitors: Profiling Hits through the Multitude of Structural Classes

PDE4 Inhibitors: Profiling Hits through the Multitude of Structural Classes

Cyclic nucleotide phosphodiesterases 4 (PDE4) are a family of enzymes which specifically promote the hydrolysis and degradation of cAMP. The inhibition of PDE4 enzymes has been widely investigated as a possible alternative strategy for the treatment of a variety of respiratory diseases, including ch...

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Bibliographic Details
Main Authors: Jian Jin, Francesca Mazzacuva, Letizia Crocetti, Maria Paola Giovannoni, Agostino Cilibrizzi
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
phosphodiesterases 4
PDE4 inhibitors
structural analysis
PDE4 selectivity
respiratory diseases
dual activity
Online Access:https://www.mdpi.com/1422-0067/24/14/11518

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