Expression and Role of Ubiquitin-Specific Peptidases in Osteoblasts
The ubiquitin-proteasome system regulates biological processes in normal and diseased states. Recent investigations have focused on ubiquitin-dependent modifications and their impacts on cellular function, commitment, and differentiation. Ubiquitination is reversed by deubiquitinases, including ubiq...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/14/7746 |
| _version_ | 1797526884138876928 |
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| author | Hadla Hariri René St-Arnaud |
| author_facet | Hadla Hariri René St-Arnaud |
| author_sort | Hadla Hariri |
| collection | DOAJ |
| description | The ubiquitin-proteasome system regulates biological processes in normal and diseased states. Recent investigations have focused on ubiquitin-dependent modifications and their impacts on cellular function, commitment, and differentiation. Ubiquitination is reversed by deubiquitinases, including ubiquitin-specific peptidases (USPs), whose roles have been widely investigated. In this review, we explore recent findings highlighting the regulatory functions of USPs in osteoblasts and providing insight into the molecular mechanisms governing their actions during bone formation. We also give a brief overview of our work on USP53, a target of PTH in osteoblasts and a regulator of mesenchymal cell lineage fate decisions. Emerging evidence addresses questions pertaining to the complex layers of regulation exerted by USPs on osteoblast signaling. We provide a short overview of our and others’ understanding of how USPs modulate osteoblastogenesis. However, further studies using knockout mouse models are needed to fully understand the mechanisms underpinning USPs actions. |
| first_indexed | 2024-03-10T09:36:38Z |
| format | Article |
| id | doaj.art-caa11b48c9dd488ab2fcc0040dc51bc7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:36:38Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-caa11b48c9dd488ab2fcc0040dc51bc72023-11-22T04:03:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012214774610.3390/ijms22147746Expression and Role of Ubiquitin-Specific Peptidases in OsteoblastsHadla Hariri0René St-Arnaud1Research Centre, Shriners Hospital for Children, Montreal, QC H4A 0A9, CanadaResearch Centre, Shriners Hospital for Children, Montreal, QC H4A 0A9, CanadaThe ubiquitin-proteasome system regulates biological processes in normal and diseased states. Recent investigations have focused on ubiquitin-dependent modifications and their impacts on cellular function, commitment, and differentiation. Ubiquitination is reversed by deubiquitinases, including ubiquitin-specific peptidases (USPs), whose roles have been widely investigated. In this review, we explore recent findings highlighting the regulatory functions of USPs in osteoblasts and providing insight into the molecular mechanisms governing their actions during bone formation. We also give a brief overview of our work on USP53, a target of PTH in osteoblasts and a regulator of mesenchymal cell lineage fate decisions. Emerging evidence addresses questions pertaining to the complex layers of regulation exerted by USPs on osteoblast signaling. We provide a short overview of our and others’ understanding of how USPs modulate osteoblastogenesis. However, further studies using knockout mouse models are needed to fully understand the mechanisms underpinning USPs actions.https://www.mdpi.com/1422-0067/22/14/7746osteoblastUSPsubiquitinboneskeletaldifferentiation |
| spellingShingle | Hadla Hariri René St-Arnaud Expression and Role of Ubiquitin-Specific Peptidases in Osteoblasts International Journal of Molecular Sciences osteoblast USPs ubiquitin bone skeletal differentiation |
| title | Expression and Role of Ubiquitin-Specific Peptidases in Osteoblasts |
| title_full | Expression and Role of Ubiquitin-Specific Peptidases in Osteoblasts |
| title_fullStr | Expression and Role of Ubiquitin-Specific Peptidases in Osteoblasts |
| title_full_unstemmed | Expression and Role of Ubiquitin-Specific Peptidases in Osteoblasts |
| title_short | Expression and Role of Ubiquitin-Specific Peptidases in Osteoblasts |
| title_sort | expression and role of ubiquitin specific peptidases in osteoblasts |
| topic | osteoblast USPs ubiquitin bone skeletal differentiation |
| url | https://www.mdpi.com/1422-0067/22/14/7746 |
| work_keys_str_mv | AT hadlahariri expressionandroleofubiquitinspecificpeptidasesinosteoblasts AT renestarnaud expressionandroleofubiquitinspecificpeptidasesinosteoblasts |