First Isolation of <i>Yarrowia lipolytica</i> in a Granulomatous Pneumonia of a Spectacled Caiman, <i>Caiman crocodilus</i> Linnaeus, 1758
Contrary to humans, candidiasis is a rare infection in animals. However, in reptiles, candidiasis can cause gastrointestinal, cutaneous, or rarely systemic infections in stressed animals. The infections due to <i>Yarrowia lipolytica</i> have been increasingly described in human medicine,...
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MDPI AG
2022-10-01
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| author | Manuela Iurescia Andrea Santini Marco Montagnani Elena Lavinia Diaconu Fiorentino Stravino Devid Agnelli Emanuela Vergari Gianluca Fichi Claudia Eleni |
| author_facet | Manuela Iurescia Andrea Santini Marco Montagnani Elena Lavinia Diaconu Fiorentino Stravino Devid Agnelli Emanuela Vergari Gianluca Fichi Claudia Eleni |
| author_sort | Manuela Iurescia |
| collection | DOAJ |
| description | Contrary to humans, candidiasis is a rare infection in animals. However, in reptiles, candidiasis can cause gastrointestinal, cutaneous, or rarely systemic infections in stressed animals. The infections due to <i>Yarrowia lipolytica</i> have been increasingly described in human medicine, and hundreds of cases are reported, comprised of granulomatous lung lesions. Herein, granulomatous pneumonia of a spectacled caiman, <i>Caiman crocodilus</i>, was described, and the presence of <i>Y. lipolytica</i> in the lesion was confirmed through histopathology, microbiologic cultures, and molecular methods. The cause of death of the spectacled caiman was ascribed to bacterial shock septicemia consequentially to a traumatic lesion. However, in the right lung, several nodules containing white exudate were evidenced. At mycological and molecular analyses, <i>Y. lipolytica</i> was evidenced, and the histological finding confirmed the presence of a <i>Candida</i> infection in the lung granulomatous lesions. The comparison of ITS sequences with 11 <i>Yarrowia</i> spp. isolates, recently described in green sea turtles, and with a human strain was conducted, and the whole genome of a strain isolated in the spectacled caiman was sequenced. Even though <i>Y. lipolytica</i> is considered a non-pathogenic yeast and has been rarely described in animals, it seems to cause granulomatous lesions in reptiles as in humans. |
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| last_indexed | 2024-03-09T18:46:22Z |
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| spelling | doaj.art-caa17d20b95b48ce894c920fc389e0b62023-11-24T06:16:35ZengMDPI AGPathogens2076-08172022-10-011111125510.3390/pathogens11111255First Isolation of <i>Yarrowia lipolytica</i> in a Granulomatous Pneumonia of a Spectacled Caiman, <i>Caiman crocodilus</i> Linnaeus, 1758Manuela Iurescia0Andrea Santini1Marco Montagnani2Elena Lavinia Diaconu3Fiorentino Stravino4Devid Agnelli5Emanuela Vergari6Gianluca Fichi7Claudia Eleni8Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, 00178 Roma, ItalyIstituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, 58100 Grosseto, ItalyIstituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, 58100 Grosseto, ItalyIstituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, 00178 Roma, ItalyIstituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, 00178 Roma, ItalyIstituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, 58100 Grosseto, ItalyIstituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, 58100 Grosseto, ItalyIstituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, 58100 Grosseto, ItalyIstituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, 00178 Roma, ItalyContrary to humans, candidiasis is a rare infection in animals. However, in reptiles, candidiasis can cause gastrointestinal, cutaneous, or rarely systemic infections in stressed animals. The infections due to <i>Yarrowia lipolytica</i> have been increasingly described in human medicine, and hundreds of cases are reported, comprised of granulomatous lung lesions. Herein, granulomatous pneumonia of a spectacled caiman, <i>Caiman crocodilus</i>, was described, and the presence of <i>Y. lipolytica</i> in the lesion was confirmed through histopathology, microbiologic cultures, and molecular methods. The cause of death of the spectacled caiman was ascribed to bacterial shock septicemia consequentially to a traumatic lesion. However, in the right lung, several nodules containing white exudate were evidenced. At mycological and molecular analyses, <i>Y. lipolytica</i> was evidenced, and the histological finding confirmed the presence of a <i>Candida</i> infection in the lung granulomatous lesions. The comparison of ITS sequences with 11 <i>Yarrowia</i> spp. isolates, recently described in green sea turtles, and with a human strain was conducted, and the whole genome of a strain isolated in the spectacled caiman was sequenced. Even though <i>Y. lipolytica</i> is considered a non-pathogenic yeast and has been rarely described in animals, it seems to cause granulomatous lesions in reptiles as in humans.https://www.mdpi.com/2076-0817/11/11/1255granulomatous pneumonia<i>Candida pneumonia</i><i>Yarrowia lipolytica</i>WGScaiman |
| spellingShingle | Manuela Iurescia Andrea Santini Marco Montagnani Elena Lavinia Diaconu Fiorentino Stravino Devid Agnelli Emanuela Vergari Gianluca Fichi Claudia Eleni First Isolation of <i>Yarrowia lipolytica</i> in a Granulomatous Pneumonia of a Spectacled Caiman, <i>Caiman crocodilus</i> Linnaeus, 1758 Pathogens granulomatous pneumonia <i>Candida pneumonia</i> <i>Yarrowia lipolytica</i> WGS caiman |
| title | First Isolation of <i>Yarrowia lipolytica</i> in a Granulomatous Pneumonia of a Spectacled Caiman, <i>Caiman crocodilus</i> Linnaeus, 1758 |
| title_full | First Isolation of <i>Yarrowia lipolytica</i> in a Granulomatous Pneumonia of a Spectacled Caiman, <i>Caiman crocodilus</i> Linnaeus, 1758 |
| title_fullStr | First Isolation of <i>Yarrowia lipolytica</i> in a Granulomatous Pneumonia of a Spectacled Caiman, <i>Caiman crocodilus</i> Linnaeus, 1758 |
| title_full_unstemmed | First Isolation of <i>Yarrowia lipolytica</i> in a Granulomatous Pneumonia of a Spectacled Caiman, <i>Caiman crocodilus</i> Linnaeus, 1758 |
| title_short | First Isolation of <i>Yarrowia lipolytica</i> in a Granulomatous Pneumonia of a Spectacled Caiman, <i>Caiman crocodilus</i> Linnaeus, 1758 |
| title_sort | first isolation of i yarrowia lipolytica i in a granulomatous pneumonia of a spectacled caiman i caiman crocodilus i linnaeus 1758 |
| topic | granulomatous pneumonia <i>Candida pneumonia</i> <i>Yarrowia lipolytica</i> WGS caiman |
| url | https://www.mdpi.com/2076-0817/11/11/1255 |
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