Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats
Background and purpose: Stressful events in early-life induce metabolic disorders in adolescence. The aim of this study was to investigate the effect of early-life stress on number or area of Langerhans islets in exposure to foot-shock and psychological stress in male rats. Materials and methods: Th...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2020-02-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
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| Online Access: | http://jmums.mazums.ac.ir/article-1-14423-en.html |
| _version_ | 1797944099494428672 |
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| author | Homeira Zardooz Forouzan Sadeghimahalli Mina Salimi |
| author_facet | Homeira Zardooz Forouzan Sadeghimahalli Mina Salimi |
| author_sort | Homeira Zardooz |
| collection | DOAJ |
| description | Background and purpose: Stressful events in early-life induce metabolic disorders in adolescence. The aim of this study was to investigate the effect of early-life stress on number or area of Langerhans islets in exposure to foot-shock and psychological stress in male rats.
Materials and methods: The rats were divided into six groups: control (without stress), early-stress (stress at 2 weeks of age), pubertal-foot shock (at 8-10 weeks of age), pubertal-psychological stress (psychological stress at 8-10 weeks of age), early-stress + pubertal-foot shock (stress at 2 weeks and foot-shock at 8-10 weeks of age), early-stress + pubertal-psychological stress (early-stress at 2 weeks and psychological stress at 8-10 weeks of age). Stress was induced for five consecutive days (twice daily). At the end of the experiment, following anesthesia with pentobarbital, the rats were decapitated and dissected to remove pancreas tissue to measure the number and area of islets.
Results: Early-life and pubertal stresses alone did not change the number or area of islets. Compared to other interventions, early-life psychological-stress could considerably change the number or area of pancreatic islets.
Conclusion: Early life stress predisposes the organism to morphological changes in endocrine pancreas as an increase in Langerhans islets number or area in exposure to stress later in life. |
| first_indexed | 2024-04-10T20:33:18Z |
| format | Article |
| id | doaj.art-caa492ba8dea425a9a568b83f9caaacd |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:33:18Z |
| publishDate | 2020-02-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-caa492ba8dea425a9a568b83f9caaacd2023-01-25T05:06:32ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792020-02-01291829198Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male RatsHomeira Zardooz0Forouzan Sadeghimahalli1Mina Salimi2 Associat Professor, Neurophysiology Research Center, Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Assistant Professor, Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran Department of Physiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Associat Professor, Neurophysiology Research Center, Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Background and purpose: Stressful events in early-life induce metabolic disorders in adolescence. The aim of this study was to investigate the effect of early-life stress on number or area of Langerhans islets in exposure to foot-shock and psychological stress in male rats. Materials and methods: The rats were divided into six groups: control (without stress), early-stress (stress at 2 weeks of age), pubertal-foot shock (at 8-10 weeks of age), pubertal-psychological stress (psychological stress at 8-10 weeks of age), early-stress + pubertal-foot shock (stress at 2 weeks and foot-shock at 8-10 weeks of age), early-stress + pubertal-psychological stress (early-stress at 2 weeks and psychological stress at 8-10 weeks of age). Stress was induced for five consecutive days (twice daily). At the end of the experiment, following anesthesia with pentobarbital, the rats were decapitated and dissected to remove pancreas tissue to measure the number and area of islets. Results: Early-life and pubertal stresses alone did not change the number or area of islets. Compared to other interventions, early-life psychological-stress could considerably change the number or area of pancreatic islets. Conclusion: Early life stress predisposes the organism to morphological changes in endocrine pancreas as an increase in Langerhans islets number or area in exposure to stress later in life.http://jmums.mazums.ac.ir/article-1-14423-en.htmlearly life stresspsychological stressphysical stresslangerhans islets |
| spellingShingle | Homeira Zardooz Forouzan Sadeghimahalli Mina Salimi Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats Journal of Mazandaran University of Medical Sciences early life stress psychological stress physical stress langerhans islets |
| title | Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats |
| title_full | Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats |
| title_fullStr | Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats |
| title_full_unstemmed | Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats |
| title_short | Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats |
| title_sort | histological evaluation of pancreas following early life stress in exposure to pubertal stress in male rats |
| topic | early life stress psychological stress physical stress langerhans islets |
| url | http://jmums.mazums.ac.ir/article-1-14423-en.html |
| work_keys_str_mv | AT homeirazardooz histologicalevaluationofpancreasfollowingearlylifestressinexposuretopubertalstressinmalerats AT forouzansadeghimahalli histologicalevaluationofpancreasfollowingearlylifestressinexposuretopubertalstressinmalerats AT minasalimi histologicalevaluationofpancreasfollowingearlylifestressinexposuretopubertalstressinmalerats |