Mechanical and matrix effects of short and long-duration exposure to beta-aminopropionitrile in elastase-induced model abdominal aortic aneurysm in mice

Mechanical and matrix effects of short and long-duration exposure to beta-aminopropionitrile in elastase-induced model abdominal aortic aneurysm in mice

Objective: Evaluate the mechanical and matrix effects on abdominal aortic aneurysms (AAA) during the initial aortic dilation and after prolonged exposure to beta-aminopropionitrile (BAPN) in a topical elastase AAA model. Methods: Abdominal aortae of C57/BL6 mice were exposed to topical elastase with...

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Bibliographic Details
Main Authors: Pete H. Gueldner, BS, Ande X. Marini, BS, Bo Li, MD, MS, Cyrus J. Darvish, BS, Timothy K. Chung, PhD, Justin S. Weinbaum, PhD, John A. Curci, MD, David A. Vorp, PhD
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:JVS - Vascular Science
Subjects:
Abdominal aortic aneurysm
BAPN model
Elastase model
Mouse model
Ninhydrin and hydroxyproline
Uniaxial ring testing
Online Access:http://www.sciencedirect.com/science/article/pii/S2666350323000020

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