Evaluation of lipid profile, high-sensitivity C-reactive protein and D-dimer in users of oral contraceptives of different types
ABSTRACT Introduction: The use of oral contraceptives increases women's risk of developing cardiovascular and thromboembolic diseases, due to alterations in hemostatic and lipid profile. Objectives: Analyze the association between the use of different types of oral contraceptives with lipid p...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Patologia Clínica
2018-02-01
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| Series: | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000100014&tlng=en |
| _version_ | 1798015195557134336 |
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| author | João Victor M. Guedes Natália R. Nunes Letícia G. R. Ferreira Thaís G. Vilar Melina B. Pinheiro Caroline P. Domingueti |
| author_facet | João Victor M. Guedes Natália R. Nunes Letícia G. R. Ferreira Thaís G. Vilar Melina B. Pinheiro Caroline P. Domingueti |
| author_sort | João Victor M. Guedes |
| collection | DOAJ |
| description | ABSTRACT Introduction: The use of oral contraceptives increases women's risk of developing cardiovascular and thromboembolic diseases, due to alterations in hemostatic and lipid profile. Objectives: Analyze the association between the use of different types of oral contraceptives with lipid profile and levels of serum high-sensitivity C-reactive protein (hsCRP) and plasma D-dimer. Methods: One hundred fifty-four participants were divided into the following groups: control nonusers (n = 41), medium-dose users (n= 32), third-generation low-dose users (n = 40), and fourth-generation low-dose users (n = 41). Triglycerides and total cholesterol serum levels were determined by colorimetric enzymatic method; high-density lipoprotein (HDL) cholesterol levels, by precipitation method; low-density lipoprotein (LDL) cholesterol levels, by Friedewald equation; hsCRP levels, by immunoturbidimetric method; and D-dimer levels, by fluorescence immunoassay. Results: Oral contraceptive users had higher serum levels of triglycerides, total cholesterol, HDL cholesterol (HDL-C), HDL/LDL index and hsCRP compared to controls. Medium-dose users had higher D-dimer plasma levels than controls and higher triglycerides serum levels than low-dose users. Triglycerides, hsCRP and D-dimer were positively correlated to each other. Conclusion: The use of combined oral contraceptives was associated with an unfavorable lipid profile and a chronic subclinical inflammation, with atherogenic potential. Furthermore, medium-dose contraceptives induced a higher thrombogenic potential, since they were associated with increased D-dimer levels in comparison to low-dose ones. |
| first_indexed | 2024-04-11T15:29:34Z |
| format | Article |
| id | doaj.art-caa8f5556e244c39b3ee9e15061f3e8a |
| institution | Directory Open Access Journal |
| issn | 1678-4774 |
| language | English |
| last_indexed | 2024-04-11T15:29:34Z |
| publishDate | 2018-02-01 |
| publisher | Sociedade Brasileira de Patologia Clínica |
| record_format | Article |
| series | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| spelling | doaj.art-caa8f5556e244c39b3ee9e15061f3e8a2022-12-22T04:16:10ZengSociedade Brasileira de Patologia ClínicaJornal Brasileiro de Patologia e Medicina Laboratorial1678-47742018-02-01541142010.5935/1676-2444.20180002Evaluation of lipid profile, high-sensitivity C-reactive protein and D-dimer in users of oral contraceptives of different typesJoão Victor M. GuedesNatália R. NunesLetícia G. R. FerreiraThaís G. VilarMelina B. PinheiroCaroline P. DominguetiABSTRACT Introduction: The use of oral contraceptives increases women's risk of developing cardiovascular and thromboembolic diseases, due to alterations in hemostatic and lipid profile. Objectives: Analyze the association between the use of different types of oral contraceptives with lipid profile and levels of serum high-sensitivity C-reactive protein (hsCRP) and plasma D-dimer. Methods: One hundred fifty-four participants were divided into the following groups: control nonusers (n = 41), medium-dose users (n= 32), third-generation low-dose users (n = 40), and fourth-generation low-dose users (n = 41). Triglycerides and total cholesterol serum levels were determined by colorimetric enzymatic method; high-density lipoprotein (HDL) cholesterol levels, by precipitation method; low-density lipoprotein (LDL) cholesterol levels, by Friedewald equation; hsCRP levels, by immunoturbidimetric method; and D-dimer levels, by fluorescence immunoassay. Results: Oral contraceptive users had higher serum levels of triglycerides, total cholesterol, HDL cholesterol (HDL-C), HDL/LDL index and hsCRP compared to controls. Medium-dose users had higher D-dimer plasma levels than controls and higher triglycerides serum levels than low-dose users. Triglycerides, hsCRP and D-dimer were positively correlated to each other. Conclusion: The use of combined oral contraceptives was associated with an unfavorable lipid profile and a chronic subclinical inflammation, with atherogenic potential. Furthermore, medium-dose contraceptives induced a higher thrombogenic potential, since they were associated with increased D-dimer levels in comparison to low-dose ones.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000100014&tlng=enoral combined contraceptivesinflammationlipidsthrombophilia |
| spellingShingle | João Victor M. Guedes Natália R. Nunes Letícia G. R. Ferreira Thaís G. Vilar Melina B. Pinheiro Caroline P. Domingueti Evaluation of lipid profile, high-sensitivity C-reactive protein and D-dimer in users of oral contraceptives of different types Jornal Brasileiro de Patologia e Medicina Laboratorial oral combined contraceptives inflammation lipids thrombophilia |
| title | Evaluation of lipid profile, high-sensitivity C-reactive protein and D-dimer in users of oral contraceptives of different types |
| title_full | Evaluation of lipid profile, high-sensitivity C-reactive protein and D-dimer in users of oral contraceptives of different types |
| title_fullStr | Evaluation of lipid profile, high-sensitivity C-reactive protein and D-dimer in users of oral contraceptives of different types |
| title_full_unstemmed | Evaluation of lipid profile, high-sensitivity C-reactive protein and D-dimer in users of oral contraceptives of different types |
| title_short | Evaluation of lipid profile, high-sensitivity C-reactive protein and D-dimer in users of oral contraceptives of different types |
| title_sort | evaluation of lipid profile high sensitivity c reactive protein and d dimer in users of oral contraceptives of different types |
| topic | oral combined contraceptives inflammation lipids thrombophilia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000100014&tlng=en |
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