Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA
Protein modification by the small ubiquitin-like modifier (SUMO) plays an important role in multiple plant processes, including growth, development, and the response to abiotic stresses. Mechanistically, SUMOylation is a sequential multi-enzymatic process where SUMO E3 ligases accelerate SUMO conjug...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Plant Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2021.652170/full |
| _version_ | 1818363518454333440 |
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| author | Souleimen Jmii Laurent Cappadocia |
| author_facet | Souleimen Jmii Laurent Cappadocia |
| author_sort | Souleimen Jmii |
| collection | DOAJ |
| description | Protein modification by the small ubiquitin-like modifier (SUMO) plays an important role in multiple plant processes, including growth, development, and the response to abiotic stresses. Mechanistically, SUMOylation is a sequential multi-enzymatic process where SUMO E3 ligases accelerate SUMO conjugation while also influencing target identity and interactions. This review explores the biological functions of plant SUMO E3 ligases [SAP AND MIZ1 DOMAIN-CONTAINING LIGASE (SIZs), METHYL METHANESULFONATE-SENSITIVITY PROTEIN 21 (MMS21s), and PROTEIN INHIBITOR OF ACTIVATED STAT-LIKE (PIALs)] in relation to their molecular activities and domains. We also explore the sub-cellular localization of SUMO E3 ligases and review evidence suggesting a connection between certain SUMO E3 ligases and DNA that contributes to gene expression regulation. |
| first_indexed | 2024-12-13T21:49:45Z |
| format | Article |
| id | doaj.art-caa98455e7884ddda7f9c78142adf91c |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-13T21:49:45Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-caa98455e7884ddda7f9c78142adf91c2022-12-21T23:30:18ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2021-04-011210.3389/fpls.2021.652170652170Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNASouleimen JmiiLaurent CappadociaProtein modification by the small ubiquitin-like modifier (SUMO) plays an important role in multiple plant processes, including growth, development, and the response to abiotic stresses. Mechanistically, SUMOylation is a sequential multi-enzymatic process where SUMO E3 ligases accelerate SUMO conjugation while also influencing target identity and interactions. This review explores the biological functions of plant SUMO E3 ligases [SAP AND MIZ1 DOMAIN-CONTAINING LIGASE (SIZs), METHYL METHANESULFONATE-SENSITIVITY PROTEIN 21 (MMS21s), and PROTEIN INHIBITOR OF ACTIVATED STAT-LIKE (PIALs)] in relation to their molecular activities and domains. We also explore the sub-cellular localization of SUMO E3 ligases and review evidence suggesting a connection between certain SUMO E3 ligases and DNA that contributes to gene expression regulation.https://www.frontiersin.org/articles/10.3389/fpls.2021.652170/fullSUMOylationSUMO E3 ligasesabiotic stressstructure-function analysisDNA-binding proteins |
| spellingShingle | Souleimen Jmii Laurent Cappadocia Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA Frontiers in Plant Science SUMOylation SUMO E3 ligases abiotic stress structure-function analysis DNA-binding proteins |
| title | Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA |
| title_full | Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA |
| title_fullStr | Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA |
| title_full_unstemmed | Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA |
| title_short | Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA |
| title_sort | plant sumo e3 ligases function structural organization and connection with dna |
| topic | SUMOylation SUMO E3 ligases abiotic stress structure-function analysis DNA-binding proteins |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2021.652170/full |
| work_keys_str_mv | AT souleimenjmii plantsumoe3ligasesfunctionstructuralorganizationandconnectionwithdna AT laurentcappadocia plantsumoe3ligasesfunctionstructuralorganizationandconnectionwithdna |