Impact of short-term traffic-related air pollution on the metabolome – Results from two metabolome-wide experimental studies
Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes but underlying biological mechanisms remain poorly understood. Two randomized crossover trials were used here, the Oxford Street II (London) and the TAPAS II (Barcelona) studies, where volunteers were a...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-02-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412018314703 |
| _version_ | 1828241169144872960 |
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| author | Karin van Veldhoven Agneta Kiss Pekka Keski-Rahkonen Nivonirina Robinot Augustin Scalbert Paul Cullinan Kian Fan Chung Peter Collins Rudy Sinharay Benjamin M. Barratt Mark Nieuwenhuijsen Albert Ambros Rodoreda Glòria Carrasco-Turigas Jelle Vlaanderen Roel Vermeulen Lützen Portengen Soterios A. Kyrtopoulos Erica Ponzi Marc Chadeau-Hyam Paolo Vineis |
| author_facet | Karin van Veldhoven Agneta Kiss Pekka Keski-Rahkonen Nivonirina Robinot Augustin Scalbert Paul Cullinan Kian Fan Chung Peter Collins Rudy Sinharay Benjamin M. Barratt Mark Nieuwenhuijsen Albert Ambros Rodoreda Glòria Carrasco-Turigas Jelle Vlaanderen Roel Vermeulen Lützen Portengen Soterios A. Kyrtopoulos Erica Ponzi Marc Chadeau-Hyam Paolo Vineis |
| author_sort | Karin van Veldhoven |
| collection | DOAJ |
| description | Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes but underlying biological mechanisms remain poorly understood. Two randomized crossover trials were used here, the Oxford Street II (London) and the TAPAS II (Barcelona) studies, where volunteers were allocated to high or low air pollution exposures. The two locations represent different exposure scenarios, with Oxford Street characterized by diesel vehicles and Barcelona by normal mixed urban traffic. Levels of five and four pollutants were measured, respectively, using personal exposure monitoring devices. Serum samples were used for metabolomic profiling. The association between TRAP and levels of each metabolic feature was assessed. All pollutant levels were significantly higher at the high pollution sites. 29 and 77 metabolic features were associated with at least one pollutant in the Oxford Street II and TAPAS II studies, respectively, which related to 17 and 30 metabolic compounds. Little overlap was observed across pollutants for metabolic features, suggesting that different pollutants may affect levels of different metabolic features. After observing the annotated compounds, the main pathway suggested in Oxford Street II in association with NO2 was the acyl-carnitine pathway, previously found to be associated with cardio-respiratory disease. No overlap was found between the metabolic features identified in the two studies. Keywords: Traffic related air pollution, Metabolomics, Randomized crossover trials |
| first_indexed | 2024-04-12T21:54:25Z |
| format | Article |
| id | doaj.art-caaa34004d62416bb92ee5ee8ad30102 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-12T21:54:25Z |
| publishDate | 2019-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-caaa34004d62416bb92ee5ee8ad301022022-12-22T03:15:22ZengElsevierEnvironment International0160-41202019-02-01123124131Impact of short-term traffic-related air pollution on the metabolome – Results from two metabolome-wide experimental studiesKarin van Veldhoven0Agneta Kiss1Pekka Keski-Rahkonen2Nivonirina Robinot3Augustin Scalbert4Paul Cullinan5Kian Fan Chung6Peter Collins7Rudy Sinharay8Benjamin M. Barratt9Mark Nieuwenhuijsen10Albert Ambros Rodoreda11Glòria Carrasco-Turigas12Jelle Vlaanderen13Roel Vermeulen14Lützen Portengen15Soterios A. Kyrtopoulos16Erica Ponzi17Marc Chadeau-Hyam18Paolo Vineis19MRC/PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United KingdomInternational Agency for Research on Cancer (IARC), Lyon, FranceInternational Agency for Research on Cancer (IARC), Lyon, FranceInternational Agency for Research on Cancer (IARC), Lyon, FranceInternational Agency for Research on Cancer (IARC), Lyon, FranceNational Heart & Lung Institute, Imperial College London, United Kingdom; Royal Brompton & Harefield NHS Trust, London, United KingdomNational Heart & Lung Institute, Imperial College London, United Kingdom; Royal Brompton & Harefield NHS Trust, London, United Kingdom; King's College London, United KingdomNational Heart & Lung Institute, Imperial College London, United Kingdom; Royal Brompton & Harefield NHS Trust, London, United KingdomNational Heart & Lung Institute, Imperial College London, United Kingdom; Royal Brompton & Harefield NHS Trust, London, United KingdomKing's College London, United KingdomBarcelona Institute for Global Health (ISGlobal), Barcelona, SpainBarcelona Institute for Global Health (ISGlobal), Barcelona, SpainBarcelona Institute for Global Health (ISGlobal), Barcelona, SpainInstitute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the NetherlandsInstitute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the NetherlandsInstitute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the NetherlandsNational Hellenic Research Foundation, Athens, GreeceMRC/PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, SwitzerlandMRC/PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the NetherlandsMRC/PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Italian Institute for Genomic Medicine (IIGM), Turin, Italy; Corresponding author at: MRC/PHE Centre for Environment and Health, School of Public Health, Imperial College London, St Mary's Campus, Room 511, Norfolk Place, W2 1PG London, United Kingdom.Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes but underlying biological mechanisms remain poorly understood. Two randomized crossover trials were used here, the Oxford Street II (London) and the TAPAS II (Barcelona) studies, where volunteers were allocated to high or low air pollution exposures. The two locations represent different exposure scenarios, with Oxford Street characterized by diesel vehicles and Barcelona by normal mixed urban traffic. Levels of five and four pollutants were measured, respectively, using personal exposure monitoring devices. Serum samples were used for metabolomic profiling. The association between TRAP and levels of each metabolic feature was assessed. All pollutant levels were significantly higher at the high pollution sites. 29 and 77 metabolic features were associated with at least one pollutant in the Oxford Street II and TAPAS II studies, respectively, which related to 17 and 30 metabolic compounds. Little overlap was observed across pollutants for metabolic features, suggesting that different pollutants may affect levels of different metabolic features. After observing the annotated compounds, the main pathway suggested in Oxford Street II in association with NO2 was the acyl-carnitine pathway, previously found to be associated with cardio-respiratory disease. No overlap was found between the metabolic features identified in the two studies. Keywords: Traffic related air pollution, Metabolomics, Randomized crossover trialshttp://www.sciencedirect.com/science/article/pii/S0160412018314703 |
| spellingShingle | Karin van Veldhoven Agneta Kiss Pekka Keski-Rahkonen Nivonirina Robinot Augustin Scalbert Paul Cullinan Kian Fan Chung Peter Collins Rudy Sinharay Benjamin M. Barratt Mark Nieuwenhuijsen Albert Ambros Rodoreda Glòria Carrasco-Turigas Jelle Vlaanderen Roel Vermeulen Lützen Portengen Soterios A. Kyrtopoulos Erica Ponzi Marc Chadeau-Hyam Paolo Vineis Impact of short-term traffic-related air pollution on the metabolome – Results from two metabolome-wide experimental studies Environment International |
| title | Impact of short-term traffic-related air pollution on the metabolome – Results from two metabolome-wide experimental studies |
| title_full | Impact of short-term traffic-related air pollution on the metabolome – Results from two metabolome-wide experimental studies |
| title_fullStr | Impact of short-term traffic-related air pollution on the metabolome – Results from two metabolome-wide experimental studies |
| title_full_unstemmed | Impact of short-term traffic-related air pollution on the metabolome – Results from two metabolome-wide experimental studies |
| title_short | Impact of short-term traffic-related air pollution on the metabolome – Results from two metabolome-wide experimental studies |
| title_sort | impact of short term traffic related air pollution on the metabolome results from two metabolome wide experimental studies |
| url | http://www.sciencedirect.com/science/article/pii/S0160412018314703 |
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