Comparison of first and second waves of COVID-19 through severity markers in ICU patients of a developing country
Background: Many countries are experiencing outbreaks of the second wave of COVID-19 infection. With these outbreaks, the severity of the disease is still ambiguously projected. Certain inflammatory markers are known to be associated with the severity of the disease and regular monitoring of these b...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Greater Baltimore Medical Center
2021-09-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20009666.2021.1949793 |
| _version_ | 1797967680867663872 |
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| author | Muhammad Sohaib Asghar Farah Yasmin Muhammad Nadeem Ahsan Haris Alvi Pahnwatt Taweesedt Salim Surani |
| author_facet | Muhammad Sohaib Asghar Farah Yasmin Muhammad Nadeem Ahsan Haris Alvi Pahnwatt Taweesedt Salim Surani |
| author_sort | Muhammad Sohaib Asghar |
| collection | DOAJ |
| description | Background: Many countries are experiencing outbreaks of the second wave of COVID-19 infection. With these outbreaks, the severity of the disease is still ambiguously projected. Certain inflammatory markers are known to be associated with the severity of the disease and regular monitoring of these biomarkers in intensive care unit admissions is paramount to improve clinical outcomes.Objectives: This study was aimed to compare the severity markers of the patients infected during the first wave versus the second wave in an intensive care unit.Methods: We conducted a retrospective study obtaining patient’s data from hospital records, admitted during the first wave in March-May 2020, and compared the data with those COVID-19 patients admitted during the second wave from October–November 2020. A descriptive comparison was done among the patients admitted to intensive care unit (ICU) during both waves of the pandemic.Results: 92 patients from first wave and 68 patients from second wave were included in the analysis, all admitted to ICU with equal gender distribution. Increased age and length of ICU stay was observed during the first wave. BMI, in-hospital mortality and invasive ventilation were statistically indifferent between both the waves. There was significantly higher APACHE-II during first wave (p = 0.007), but SOFA at day 1 (p = 0.213) and day 7 of ICU stay remain indifferent (p = 0.119). Inflammatory markers were less severe during second wave while only neutrophils and lymphocytes were found to peak higher.Conclusion: Most of the severity markers were less intense during the early analysis of second wave. |
| first_indexed | 2024-04-11T02:34:59Z |
| format | Article |
| id | doaj.art-caaaa42e93f1466eb82b50b0971b8db7 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T02:34:59Z |
| publishDate | 2021-09-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-caaaa42e93f1466eb82b50b0971b8db72023-01-02T20:36:01ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662021-09-0111557658410.1080/20009666.2021.19497931949793Comparison of first and second waves of COVID-19 through severity markers in ICU patients of a developing countryMuhammad Sohaib Asghar0Farah Yasmin1Muhammad Nadeem Ahsan2Haris Alvi3Pahnwatt Taweesedt4Salim Surani5Dow University of Health SciencesDow Medical College, Dow University of Health SciencesDow University Hospital - Ojha Campus, Dow University of Health SciencesDow University of Health SciencesCorpus Christi Medical CenterCorpus Christi Medical Center, Internal Medicine, University of North TexasBackground: Many countries are experiencing outbreaks of the second wave of COVID-19 infection. With these outbreaks, the severity of the disease is still ambiguously projected. Certain inflammatory markers are known to be associated with the severity of the disease and regular monitoring of these biomarkers in intensive care unit admissions is paramount to improve clinical outcomes.Objectives: This study was aimed to compare the severity markers of the patients infected during the first wave versus the second wave in an intensive care unit.Methods: We conducted a retrospective study obtaining patient’s data from hospital records, admitted during the first wave in March-May 2020, and compared the data with those COVID-19 patients admitted during the second wave from October–November 2020. A descriptive comparison was done among the patients admitted to intensive care unit (ICU) during both waves of the pandemic.Results: 92 patients from first wave and 68 patients from second wave were included in the analysis, all admitted to ICU with equal gender distribution. Increased age and length of ICU stay was observed during the first wave. BMI, in-hospital mortality and invasive ventilation were statistically indifferent between both the waves. There was significantly higher APACHE-II during first wave (p = 0.007), but SOFA at day 1 (p = 0.213) and day 7 of ICU stay remain indifferent (p = 0.119). Inflammatory markers were less severe during second wave while only neutrophils and lymphocytes were found to peak higher.Conclusion: Most of the severity markers were less intense during the early analysis of second wave.http://dx.doi.org/10.1080/20009666.2021.1949793covid-19severitywavespandemicmortalitymarkers |
| spellingShingle | Muhammad Sohaib Asghar Farah Yasmin Muhammad Nadeem Ahsan Haris Alvi Pahnwatt Taweesedt Salim Surani Comparison of first and second waves of COVID-19 through severity markers in ICU patients of a developing country Journal of Community Hospital Internal Medicine Perspectives covid-19 severity waves pandemic mortality markers |
| title | Comparison of first and second waves of COVID-19 through severity markers in ICU patients of a developing country |
| title_full | Comparison of first and second waves of COVID-19 through severity markers in ICU patients of a developing country |
| title_fullStr | Comparison of first and second waves of COVID-19 through severity markers in ICU patients of a developing country |
| title_full_unstemmed | Comparison of first and second waves of COVID-19 through severity markers in ICU patients of a developing country |
| title_short | Comparison of first and second waves of COVID-19 through severity markers in ICU patients of a developing country |
| title_sort | comparison of first and second waves of covid 19 through severity markers in icu patients of a developing country |
| topic | covid-19 severity waves pandemic mortality markers |
| url | http://dx.doi.org/10.1080/20009666.2021.1949793 |
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