Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study
Background: Palmitoleic acid (omega-7) has been reported to be effective primarily for metabolic disorders. Recently, it has been reported to help improve quality of life (QoL) by improving skin symptoms. Objective: The aim of this randomized, double-blinded, placebo-controlled clinical study is to...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402303918X |
| _version_ | 1797814368992231424 |
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| author | Young Gue Koh Joon Seok Jae Wan Park Ka Ram Kim Kwang Ho Yoo Yong Joon Kim Beom Joon Kim |
| author_facet | Young Gue Koh Joon Seok Jae Wan Park Ka Ram Kim Kwang Ho Yoo Yong Joon Kim Beom Joon Kim |
| author_sort | Young Gue Koh |
| collection | DOAJ |
| description | Background: Palmitoleic acid (omega-7) has been reported to be effective primarily for metabolic disorders. Recently, it has been reported to help improve quality of life (QoL) by improving skin symptoms. Objective: The aim of this randomized, double-blinded, placebo-controlled clinical study is to evaluate the efficacy and safety of oral palmitoleic acid in improving skin barrier, elasticity, and wrinkle formation in adult women. Methods: In this randomized, double-blind, placebo-controlled clinical study, 90 healthy participants were enrolled and received 500 mg/day palmitoleic acid (intervention) or corn oil without palmitoleic acid (control) for 12 weeks. Skin hydration and transepidermal water loss and skin elasticity, surface roughness, eye wrinkle volume, and wrinkle severity were measured at 6-week intervals to assess the skin barrier function and efficacy in wrinkle improvement, respectively. Results: After 12 weeks, skin hydration and transepidermal water loss significantly improved in the intervention group compared to the control group. Skin elasticity, surface roughness, eye wrinkle volume, wrinkle severity, and participant-assessed clinical improvement score did not significantly improve compared with the control group. Conclusion: Oral palmitoleic acid effectively improves the skin barrier function improvement, which may enhance QoL in aging adults. |
| first_indexed | 2024-03-13T08:06:41Z |
| format | Article |
| id | doaj.art-caac95841e694cbd94e309361f30f468 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T08:06:41Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-caac95841e694cbd94e309361f30f4682023-06-01T04:36:38ZengElsevierHeliyon2405-84402023-06-0196e16711Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled studyYoung Gue Koh0Joon Seok1Jae Wan Park2Ka Ram Kim3Kwang Ho Yoo4Yong Joon Kim5Beom Joon Kim6Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South KoreaDepartment of Dermatology, Chung-Ang University College of Medicine, Seoul, South KoreaDepartment of Dermatology, Chung-Ang University College of Medicine, Seoul, South KoreaDepartment of Dermatology, Chung-Ang University College of Medicine, Seoul, South KoreaChung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong-si, Gyeonggi-do, Republic of KoreaOracle Clinic, Gwangjin-gu, Seoul, Republic of KoreaDepartment of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea; Corresponding author. Department of Dermatology, Chung-Ang University Hospital 102, Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.Background: Palmitoleic acid (omega-7) has been reported to be effective primarily for metabolic disorders. Recently, it has been reported to help improve quality of life (QoL) by improving skin symptoms. Objective: The aim of this randomized, double-blinded, placebo-controlled clinical study is to evaluate the efficacy and safety of oral palmitoleic acid in improving skin barrier, elasticity, and wrinkle formation in adult women. Methods: In this randomized, double-blind, placebo-controlled clinical study, 90 healthy participants were enrolled and received 500 mg/day palmitoleic acid (intervention) or corn oil without palmitoleic acid (control) for 12 weeks. Skin hydration and transepidermal water loss and skin elasticity, surface roughness, eye wrinkle volume, and wrinkle severity were measured at 6-week intervals to assess the skin barrier function and efficacy in wrinkle improvement, respectively. Results: After 12 weeks, skin hydration and transepidermal water loss significantly improved in the intervention group compared to the control group. Skin elasticity, surface roughness, eye wrinkle volume, wrinkle severity, and participant-assessed clinical improvement score did not significantly improve compared with the control group. Conclusion: Oral palmitoleic acid effectively improves the skin barrier function improvement, which may enhance QoL in aging adults.http://www.sciencedirect.com/science/article/pii/S240584402303918XOmega-7Palmitoleic acidSkin barrierSkin hydrationSkin wrinklesQuality of life |
| spellingShingle | Young Gue Koh Joon Seok Jae Wan Park Ka Ram Kim Kwang Ho Yoo Yong Joon Kim Beom Joon Kim Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study Heliyon Omega-7 Palmitoleic acid Skin barrier Skin hydration Skin wrinkles Quality of life |
| title | Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study |
| title_full | Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study |
| title_fullStr | Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study |
| title_full_unstemmed | Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study |
| title_short | Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study |
| title_sort | efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement a 12 week randomized double blinded placebo controlled study |
| topic | Omega-7 Palmitoleic acid Skin barrier Skin hydration Skin wrinkles Quality of life |
| url | http://www.sciencedirect.com/science/article/pii/S240584402303918X |
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